If the V has been working for you it would be unusual for it to all of a sudden stop. And, if it was not as effective, it would not have lasted as long for you (as it did in the past). Thus, I think that something else could be growing on.
I think I would deal with your thyroid issues first and or maybe your thyroid medication.
Other things that can effect you are lack of sleep at night. Or, have you started any new medications in the last 5 or 6 weeks?
But, to answer your question. No you normally do not build up a resistance to V that fast. In fact, once the med is dialed - it should be good for quite a long time. Unless, of course, something else is going on medically.
i hope this helps. Let me know how this woks out. Best wishes!!