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Interactions between methadone and abilify

I need to know if abilify decreases methadone? Has anyone been on these two meds at the same time? Can you tell me how it made you feel? I was prescribed abilify but haven't started it yet because I am unsure of the interaction. Some say it causes withdrawal for the methadone and some say it increases methadone, talk about confusing!! Please tell me your experience or opinion.
5 Responses
Avatar universal
Hi, Emmy. I'm not on Abilify but have a history with Methadone. I looked it up and its s a partial dopamine agonist and don't see anything that suggests it would make you go through withdrawals from Methadone. If anything I think it would increase the effects but I'm not sure. Just be careful.

How much Methadone are you on? Are you trying to come off it? Are you on it for pain management, MMT, or just abuse it? I'm only curious and it may help clarify your situation.

Good luck and let us know how you're doing.
Avatar universal
Hi Emmy-   Its recommended that Abilify not be used with any sedative type medication because it will increase it's properties.

Do you know why the doctor prescribed this? Abilify is an anti psychotic medication. I would be concerned about taking it myself without methadone! Read up about it and then speak to your doctor once more OR get a second opinion.  I think Abilify is tossed around too much and has the ability to "zombify" the world!  Just my opinion...

It's great that you posted; stay in touch!
1 Comments
Hi yeah it is effecting my dose completely I'm not sure if they did a trouph on you yet my trouph actually went down when I it mine increased.im figuring this out for my self they had no idea what was going on. This is a great website
Avatar universal
HI your best bet here is to ask the doctor at the methadone clinic it would be good to ask the prescribing doctor as well but most regular doctors know little about methadone dont take it till you have some answers............Gnarly
Avatar universal
I am prescribed methadone and I take it for back pain and previous addiction to oxycontin.  I take 60mg a day, thanks for your response!!
1 Comments
Hi I am also on methadone and Abilify and I think it is affecting the effects of the methadone let me know if you found anything out my email is mafiia.mii.***@****
Avatar universal
I'm currently prescribed 50 mg of Methadone and 10 mg Abilify but I have noticed a major increase of drowsiness. I have even lowered and started taking half of my abilify and split dosing my methadone and I have been able to function much better and much lower feeling of drowsiness through the day. I also have tired to go a day and a half without abilify and noticed restless legs. You would think its withdrawal from methadone because as addicts or simply using opiates you would feel this as a withdrawal symptom, but it's actually from the ablilfy because restlessness is a side effect. But I plan to lower my methadone tomorrow to start trying this to help with the drowsiness so I can be able to take the abilify at the right amount prescribed. So in my opinion it does increase the methadone effects. But doesn't cause withdrawal unless restlessness from the abilify when you wait longer than 24 hrs to take in again.
1 Comments
How is the lowering going?  I think you have a great plan with this.  You sound very strong!  Make sure to tell your doctor just so they know and can chart what you are doing.  Maybe even offer you some guidance. But honestly, you sound like you are doing so great.  Was the weekend good with the situation?
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