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1399363 tn?1462342610

histamine, b6 increase? or?

i was reading information about histamine intolerance and vit b6 many says vitamin b6 will increase sao so reduce histamine but i read some that says vit b6 synthesis histamine. isnt that gonna increase histamine? also citrus food are high histamine but it says vit c will help? could someone gives some inputs? thanks
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Avatar universal
MEDICAL PROFESSIONAL
Hello and hope you are doing well.

Histamine occurs naturally in certain foods and an enzyme called diamine oxidase, which is present in our body breaks down the histamine which we absorb from food. Deficiency of this enzyme can cause histamine intolerance. Among the naturally occurring fruits and vegetables some can be rich in histamines and some promote the release of histamine from mast cells. So, with consumption of food the reactions can vary. Low levels of diamine oxidase could be due to deficiency of vitamin B6 and vitamin C.

Hope this helped and do keep us posted.
Helpful - 0
1399363 tn?1462342610
thanks for the response :D
yeah i  do know that. and i just noticed i made a mistake, i meant DOA diamin oxidase. i was confused about vitamin b6 because some says it helps increase diamine oxidase but i read it synthesis histamine i was worried if its gonna increase histamine it instead. also some says low copper could caused histamine intolerance/DOA defiency.
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Avatar universal
MEDICAL PROFESSIONAL
Hello and hope you are doing well.

Agree with you, to reduce the histamine levels in the blood, you should not consume foods which are known to have high levels of histamine and you should consume food which has those vitamins or minerals which promote the formation of the enzyme diamine oxidase. Vitamin B6 and copper are needed for the production and maintenance of diamine oxidase. If there is an inherent deficiency in the production of the enzyme due to genetic factors then supplementing the vitamins or minerals will not help. You may have to take anti histamines to manage the symptoms.

Hope this helped and do keep us posted.
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1399363 tn?1462342610
so supplement/increase intake of vitamin b6, copper will not help? eventhough some says it helps. will try to increase diamine oxidase help to break down histamine? its really hard to avoid food that doesnt have histamine or low in it especially for someone who has more than 1 intolerance also since some information about it is disparate too. and many of them are nutritious food.
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Avatar universal
I have also been doing some research on histamine intolerance, having found that antihistamines are helping by reducing abdominal swelling and a bruised feeling.  I am also finding my head is clearer and I am not in such a fog as usual.

It is a little confusing when reading up on the subject.  I also saw that Vitamin C is supposed to be a natural antihistamine and then I read elsewhere that it aggravates histamine intolerance.  I guess on should maintain Vitamin C levels but avoid citrus fruits and hope for the best.

I understand that some supplements are necessary for the production of diamine oxidase.  As I understand it, what the medical professional above was saying is that these supplements can help if the natural production of diamine oxidase in your body is not happening because of deficiencies of key supplements.  However, if diamine oxidase is  low or not being produced for other reasons, maybe genetics or something, then the supplements are not going to resolve the problem.

It is clear that eating a low histamine diet is not easy at all.  Histamine is in most foods and avoiding foods with high or medium levels of histamine could easily lead to nutritional deficiencies which then cause other problems.  Personally, I have resorted to taking antihistamines and trying to avoid the highest histamine foods.  It seems to be helping.
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