Every time I try a medication that has a reuptake effect on norepeneprhine I get this mild burning sensation on the left side of my chest. So far I have had this happen with Atomoxetine, Venlafaxine, Bupropion and now Nortrypytiline. It isn't anxiety, a panic attack or heartburn, just a dull, moderately uncomfortable, burning sensation. I'm fine with all the SSRI's and medications like Rexulti. It's just the ones that affect NE. Interestingly enough I can Adderall, Modafinil and have caffeine without the same issue so it has to be some mechanism of the antidepressants. This is very annoying. I'm curious if anyone has heard of this or experiences the same issue and hoping for some suggestions to either treat the symptom or for tests I can ask to get done. Anything at all to help would be greatly appreciated.