Aa
2 parents with HLA-B27 marker
What are the chafes that a child born to 2 parents carrying the HLA-B27 gene will have Ankalosing Spondylitis? One parent has the disease.
MEDICAL PROFESSIONAL
Hi!
If you are of Scandinavian descent then HLA-B27 gene is present in about one third population and not all having this gene have ankylosing spondylitis. Also while 90 percent of people having ankylosing spondylitis have the HLA-B27 gene, but all those who have the HLA-B27 gene do not have ankylosing spondylitis. So, since both your parents have the HLA-B27 gene, you are likely to inherit it from them. However, though your chances of developing ankylosing spondylitis are higher than the general population with HLA-B27 gene (because one parent has the disease), it is not necessary that you will develop the disease. So, let say there is a 50-50 chance. This also depends on the geographical area, the incidence of ankylosing spondylitis in your area and other environmental and genetic factors. Please discuss with a specialist in your area. Take care!
The medical advice given should not be considered a substitute for medical care provided by a doctor who can examine you. The advice may not be completely correct for you as the doctor cannot examine you and does not know your complete medical history. Hence this reply to your post should only be considered as a guiding line and you must consult your doctor at the earliest for your medical problem.
If you are of Scandinavian descent then HLA-B27 gene is present in about one third population and not all having this gene have ankylosing spondylitis. Also while 90 percent of people having ankylosing spondylitis have the HLA-B27 gene, but all those who have the HLA-B27 gene do not have ankylosing spondylitis. So, since both your parents have the HLA-B27 gene, you are likely to inherit it from them. However, though your chances of developing ankylosing spondylitis are higher than the general population with HLA-B27 gene (because one parent has the disease), it is not necessary that you will develop the disease. So, let say there is a 50-50 chance. This also depends on the geographical area, the incidence of ankylosing spondylitis in your area and other environmental and genetic factors. Please discuss with a specialist in your area. Take care!
The medical advice given should not be considered a substitute for medical care provided by a doctor who can examine you. The advice may not be completely correct for you as the doctor cannot examine you and does not know your complete medical history. Hence this reply to your post should only be considered as a guiding line and you must consult your doctor at the earliest for your medical problem.
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