Aa
ANA & Calcium high also dsDNA
It's been over 2 months since all my issues or "flare up" started! Doctors found high ANA and Calcium, dsDNA, low iron and vitamin D. Vitamin D suppliment of 1000 units made things worse. My PCP says more tests are to expensive and accuse me of being on drugs!! I'm going today to get ALL my blood test results from the lab....
Sarcoidosis is a listed cause of high calcium. I found a study "Anti-dsDNA antibodies in sarcoidosis" from pubmed (PMID: 10805357) and a few excerpts from the abstract...
"The occurrence of anti-dsDNA antibodies is known to be a specific marker of systemic lupus erythematosus (SLE). Sarcoidosis can occur with SLE. It is unclear if anti-dsDNA antibodies in patients with sarcoidosis signify the eventual development of SLE."
"ANA were positive in 10 of 34 of the patients screened. Two patients with sarcoidosis had antibodies to dsDNA."
"CONCLUSIONS: Anti-dsDNA antibodies may occur in patients with sarcoidosis, but their presence does not predict the subsequent development of SLE."
"The occurrence of anti-dsDNA antibodies is known to be a specific marker of systemic lupus erythematosus (SLE). Sarcoidosis can occur with SLE. It is unclear if anti-dsDNA antibodies in patients with sarcoidosis signify the eventual development of SLE."
"ANA were positive in 10 of 34 of the patients screened. Two patients with sarcoidosis had antibodies to dsDNA."
"CONCLUSIONS: Anti-dsDNA antibodies may occur in patients with sarcoidosis, but their presence does not predict the subsequent development of SLE."
I was diagnosed with Sarcoidosis of the lungs and lymph nodes in 2007... Do you think it could be Lupus as well?!?
sDNA is highly diagnostic of systemic lupus erythematosus (SLE) and implicated in the pathogenesis of lupus nephritis (inflammation of the kidney caused by SLE). High calcium can be seen with SLE due to either the immune system targeting the parathyroid glands (extremely rare) or more commonly due to kidney problems.
Vitamin D deficiency is very common with Lupus (one study showing 96% of lupus patients deficient in vitamin D) however the body will lower vitamin D when calcium is high as a protective mechanism to prevent extra calcium being absorbed from the diet.
Anaemia is a frequent occurrence in SLE and causes include inflammation, renal (kidney) insufficiency, blood loss, dietary insufficiency, medications, hemolysis, infection, hypersplenism, myelofibrosis, myelodysplasia, and aplastic anaemia.
Vitamin D deficiency is very common with Lupus (one study showing 96% of lupus patients deficient in vitamin D) however the body will lower vitamin D when calcium is high as a protective mechanism to prevent extra calcium being absorbed from the diet.
Anaemia is a frequent occurrence in SLE and causes include inflammation, renal (kidney) insufficiency, blood loss, dietary insufficiency, medications, hemolysis, infection, hypersplenism, myelofibrosis, myelodysplasia, and aplastic anaemia.
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