Some insight please

[Poz2]

I have been suffering from tender and stinging pains all over body and a sore throat for 4 months. Unfortunately nothing Ana's been found. I have several swollen nodes that ache as well. Negative ANA, ESR. I also did antibody test for infectious diseases. Stomach feels bloated. Joint pain. Doctor and specialist said everything was normal. Looking at my copies I saw that my IGg is 591 normal range being 700-1600. Does that sound like something is down in my immune system?  Any input would help.

[Red_Star]

Sorry, I mixed a few primary causes of high IgG with secondary causes on my first answer. I am lucky I live in Australia with free health care!

[Red_Star]

Test IgG subclasses first. Here are a few examples of subclass results.

"Table V: IgG Subclass in primary immunodeficiency syndromes

Primary immunodeficiency:

IgG Subclass deficiencies:

IgA deficiency (71,72):

frequently associated with IgG2 and IgG4 deficiencies but IgG3 deficiencies may also occur as well

Common Variable Immunodeficiency (CVID) (73,74):

associated with decreased levels of IgG1, IgG2 and IgG4

Wiskott-Aldrich Syndrome (WAS) (75,76):

IgG3 and IgG4 deficiencies are observed

Ataxia telangiectasia (77,78):

IgG2 and IgG4 levels are usually very low, sometimes also associated with IgG3 deficiency

Chronic Mucocutaneous Candidiasis (79):

some patients have IgG2 and IgG4 deficiency, isolated IgG2 and IgG3 deficiencies are also observed


TABLE VI: IgG Subclasses in secondary immunodeficiency syndromes:

Secondary immunodeficiency:

IgG subclass deficiencies

HIV-infection (stages III and IV) (80,81,82):

IgG2 and IgG4 levels are often decreased, while levels of IgG1 and IgG3 are increased

Radiation exposure, chemotherapy (83,84) (bone-marrow transplantation):

often associated with low levels of IgG2 and IgG4"

[Poz2]

Thank you. Going to my primary today to order a couple of PCR tests, as well as having my subclasses checked. He also plans to do a biopsy on a small lump on the back of my neck. Hoping it's just a cyst. Thanks again for the detailed answers.

[Poz2]

This is starting to get expensive.

[Red_Star]

IgG are antibodies that protect against infection by "remembering" which germs you've been exposed to before. Low IgG means a greater chance of infection. Treatment includes antibiotics and if needed immunoglobulin therapy via injections or IV.

IgG deficiency may be primary or secondary. Primary IgG deficiency looks to be genetic.
Secondary IgG deficiency may be caused by aging, malnutrition, medicines (eg: chemotherapy, corticosteroids) or infections (eg: HIV), macroglobulinemia, nephritic syndrome, some types of leukemia and common variable immunodeficiency (CVID).

Recommended to test IgG subclasses: IgG1, IgG2, IgG3 and IgG4 as well as IgA and IgM.

[Poz2]

Thank you Red Star.

[Poz2]

Would I need to retest for the infectious diseases via PCR or other method? Or would that depend on the subclasses. I tested so far for EBV Toxo HIV Cocci(valley Fever) and others. I ask this because of the low IGg.

[Poz2]

IgA and IgM fell within normal range .