With all of your numerous symptoms, under-methylation should be ruled out.
Right, what on earth is MethylationT?
Your doctor will never tell you, yet it is one one of the few conditions which will encompass ALL of your symptoms.
Naturally, there are a number of co-factors, beyond gene mutations (MTHFR)which would cause
Methylation issues. Take some time to learn about this online. There's tons of info out there.
If your Histamine levels are high, you are likely a low methylator or you're deficient in B12 and Folate .
You need to supplement with Methylocobalamin B12, Methylfolate, B2 and B6.
As simple as that.
Also check for other deficiencies like Vitamin D, magnesium (ask for RBC electrolyte testing), thyroid hormones (test for Free T3, Free T4 AND reverse T3), saliva 4 x cortisol, estrogen dominance (check estrogen/progesterone ratio)
With family history of autoimmune disease, it is more likely autoimmune. My rheumatologist ordered an impressive list of labs. I would seek a second opinion. Also request vitamin D.
"CLINICAL ASSOCIATIONS OF pANCA
In contrast to cANCA, pANCA are not specific for a single disease entity but tend to be associated with disease groups
which share several common clinical and histological features .
pANCA are found in:
(i) systemic vasculitides such as microscopic polyarteritis, Churg-Straub syndrome, and in a minority of cases of classic polyarteritis nodosa, and rarely in secondary vasculitis;
(ii) necrotizing crescentic glomerulonephritis and rarely in other forms of glomerulonephritis;
(iii) chronic inflammatory rheumatic disorders, e.g. rheumatoid arthritis, and in Still's and Felty's syndromes;
(iv) collagen vascular diseases such as systemic lupus erythematosus (SLE), and in Sjogren's syndrome without obvious signs of vasculitis; and
(v) chronic inflammatory bowel disease and associated disorders.
On the other hand, we found pANCA in less than 3% of 400 cases with biopsy-proven WG .
Additionally, pANCA (MPO-ANCA) can be induced by drugs (hydralazine, cloza-
pine, L-tryphtophan) [91-93] which can induce diseases associated with vasculitis (e.g. glomerulonephritis , pulmonary vasculitis [45,94,95]).
Occupational exposure to environmental factors such as silica dust may provoke MPO-ANCA-associated RPGN: in these patients, the frequency of silica exposure was found to be 10 times that in a control group .
In 30% of patients suffering from Goodpasture's syndrome, ANCA were detected in addition to antibodies directed against the glomerular basement membrane ."
Clin Exp Immunol 1993; 91:1-12
REVIEW ANCA and associated diseases: immunodiagnostic and pathogenetic aspects
Most people who I know with autoimmune conditions suspected or confirmed, even the ones who had second opinions and extensive testing, have either gotten worse (majority) or have had minimal improvement (minority) while only a handful had notable improvement.
The hurdle necessary to overcome, seems to be the very same system which supposedly we trust to seek diagnosis and effective treatment.
When for example your pANKA and ANA titres are low positives, rheumatologists will generally
Finding one who works outside the recommended protocols is simply difficult, specially when you're using the public health system.
Autoimmune or not, it is totally unfair for sufferers like yourself to be left in limbo, suffering from numerous symptoms like the ones you mentioned in your post.
Approaching your case from outside the conventional box, one needs to explore potential causative factors which may lead to auto-immune or auto-immune-like diseases.
My suspicions mentioned in my earlier post are some common causative factors, which may help
shed some light.
Genetics and family history is a good start and you may want to pursue this first.
Look into MTHFR gene mutations in regards to Methylation issues, HLA-B27 in regards to PsA.
Please note that genetics alone do not necessarily cause these conditions, but presently with the advances in the field of Epigenetics we can correct some imbalances due to certain genetic defects.
Improving nutritional intake, correcting vitamin/mineral deficiencies, detoxing, rebalancing the hormonal system etc. are additional steps to consider.
A reputable functional medicine doctor or holistic practitioner may be able to help you with the above.