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What else can high antihistone antibodies indicate?
I really NEED SOMEONE with medical expertise to PLEASE help me with my puzzle... everyday there are new pieces, but they only create more questions, and still no answers! I am fairly intelligent and able to research, with a decent amount of understanding, but I'm just not finding any answers! My recent bloodwork, consistent with previous bloodwork, shows a positive ANA with 1:320 titer, and a nucleolar pattern. But the puzzling part is the antihistone antibodies 7.3, normally indicative of drug induced lupus, but I've never taken any of the drugs associated with this... so I guess my question is WHAT ELSE could this point to?? All that keeps coming up is scleroderma, but I dont feel my symptoms fit this... I do feel they fit with sle, fibromyalgia, and even ms, but what about the antihistones? One other possible clue is my BUN/Creatinine ratio is slightly out of range (22.2)
I do have Hashimotos/hypothyroidism (controlled) but a laundry list of symptoms that go way beyond this... the doctors say fibromyalgia and chronic pain syndrome, which fits some of my symptoms, but doesnt explain the lab results and MANY other symptoms ...frankly it feels like the easy and common diagnosis without looking at the whole picture!
I could go on and on, but I wont (for now!) I can provide more puzzle pieces if needed, but for now my main question is regarding the antihistones...
I've read MANY of the very helpful threads and articles provided on this site, especially those by @thelightseeker (i really hope he sees this) but NOTHING on antihistones! So I signed up and here I am... ANY clues and advice would be appreciated!
Mahalo in advance :)
I do have Hashimotos/hypothyroidism (controlled) but a laundry list of symptoms that go way beyond this... the doctors say fibromyalgia and chronic pain syndrome, which fits some of my symptoms, but doesnt explain the lab results and MANY other symptoms ...frankly it feels like the easy and common diagnosis without looking at the whole picture!
I could go on and on, but I wont (for now!) I can provide more puzzle pieces if needed, but for now my main question is regarding the antihistones...
I've read MANY of the very helpful threads and articles provided on this site, especially those by @thelightseeker (i really hope he sees this) but NOTHING on antihistones! So I signed up and here I am... ANY clues and advice would be appreciated!
Mahalo in advance :)
FP Notebook - Antihistone Antibody...
"Positive (Percentage refers to sensitivity):
A. Non-Specific (seen in many disorders)
B. Systemic Lupus Erythematosus (50%)
C. Drug induced Lupus Erythematosus (90%)"
***
"Nucleolar staining of antinuclear antibodies (ANAs) is not exclusive to patients suffering systemic sclerosis (SSc) since it can occur in other autoimmune diseases, such as systemic lupus erythematosus (SLE). The nucleolar ANA pattern presents a low incidence in patients with SLE, with less than 9% reported in some studies."*
*Serological profile and clinical features of nucleolar antinuclear pattern in patients with systemic lupus erythematosus from southwestern Spain. Lupus 2016 Aug;25(9):980-7. doi: 10.1177/0961203316629557
***
I have Hashimoto's thyroiditis as well. That was my last autoimmune disease to show up..hopefully my last! I also have autoimmune pernicious anaemia, vitiligo and alopecia areta (last one in remission).
Excerpt from Patient UK - Hashimoto's thyroiditis...
"Hashimoto's thyroiditis and hypothyroidism are associated with other autoimmune conditions:
Addison's disease.
Diabetes mellitus.
Hypogonadism.
Hypoparathyroidism.
Pernicious anaemia.
Alopecia areata, totalis and universalis.
Chronic active hepatitis.[10]
Polymyalgia rheumatica and giant cell arteritis.
Primary biliary cirrhosis.
Rheumatoid arthritis, Sjögren's syndrome, systemic lupus erythematosus.
Systemic sclerosis (scleroderma).
Vitiligo.[11]"
"Positive (Percentage refers to sensitivity):
A. Non-Specific (seen in many disorders)
B. Systemic Lupus Erythematosus (50%)
C. Drug induced Lupus Erythematosus (90%)"
***
"Nucleolar staining of antinuclear antibodies (ANAs) is not exclusive to patients suffering systemic sclerosis (SSc) since it can occur in other autoimmune diseases, such as systemic lupus erythematosus (SLE). The nucleolar ANA pattern presents a low incidence in patients with SLE, with less than 9% reported in some studies."*
*Serological profile and clinical features of nucleolar antinuclear pattern in patients with systemic lupus erythematosus from southwestern Spain. Lupus 2016 Aug;25(9):980-7. doi: 10.1177/0961203316629557
***
I have Hashimoto's thyroiditis as well. That was my last autoimmune disease to show up..hopefully my last! I also have autoimmune pernicious anaemia, vitiligo and alopecia areta (last one in remission).
Excerpt from Patient UK - Hashimoto's thyroiditis...
"Hashimoto's thyroiditis and hypothyroidism are associated with other autoimmune conditions:
Addison's disease.
Diabetes mellitus.
Hypogonadism.
Hypoparathyroidism.
Pernicious anaemia.
Alopecia areata, totalis and universalis.
Chronic active hepatitis.[10]
Polymyalgia rheumatica and giant cell arteritis.
Primary biliary cirrhosis.
Rheumatoid arthritis, Sjögren's syndrome, systemic lupus erythematosus.
Systemic sclerosis (scleroderma).
Vitiligo.[11]"
2 Comments
Thank you for taking the time to answer me :) mostly what I have found, as well... I personally still believe its SLE, but my rheumy still not convinced... I just dont fit neatly in any one box... go figure!
Good luck with a diagnosis. :)
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