Could you be more specific? There are many connective tissue diseases.
for MCTD started with swollen hands, knees and feet, very sore joints. they a bllod test. i had a very high ana with speckle pattern and a positive r n p. a normal ana is 1 - 40 mine was over 2500. with mixed connective tissue disease get a trifecta in the rhuemotology world. Lupus, RA, raynauds, sclera derma and a host of other problems that they treat symptomatically. Pill for this and a pil for that. will never go away or go lower but it can go into remission if your lucky