suboxone and oxcarbazepine

[goingcrazy169]

i have been taking suboxone for months now and my Pdr. has been trying differnt Bi-polar meds on me and after many trial and errors he has put me on oxcarbazepine, after all the bad affects I have been through mixing other meds with the suboxone I am scared to go trough it all agin does anyone know if these two meds mix ok? I am on 8mg subs 3Xs aday. any help would be great! thanks

[weaver71]

There has never been much research done on subs, for addiction recovery and especially cross medication research. There is more research on buprenorphine as a pain reliever in low dose for short term use. You won't find the answer to your question, if you do, it will be the effect the combo had on the person who tried it. I have used subs with lithium only. There seems to be no negative effect. I tapered off it as soon as the lithium was working good enough. You are taking a higher dose than is effective, if you would like me to share the research that explains all about 32mg ceiling effect of subs and half-life accumulation, let me know. Your high dose could be part of the issue you are having with other meds, but there is no proof either way. I am faiy educated on whT there is to know about that opioid.

[mercaidees]

I have done all kinds of research and i cannot get a good answer. can i do suboxone with trileptal?

[inga511]

True.

[ILADVOCATE]

  You really have to speak to your psychiatrist and doctor directly about medication interactions especially with anything that is as strong a medication as Suboxone. This is what I could find as per the interaction between Suboxone and Trileptal but all this should be discussed with your psychiatrist who could (and should be doing) a search on the physician's only database all doctors have access to. As well in the meantime you could also speak to your pharmacist and look at the medication website itself:

"MONITOR: Coadministration with drugs that are inducers of CYP450 3A4 may decrease the plasma concentrations and efficacy of buprenorphine, which is metabolized in the liver by the isoenzyme. In addition, some of these inducers (anticonvulsants and barbiturates) may have additive central nervous system-depressant effects with buprenorphine.

MANAGEMENT: Pharmacologic response to buprenorphine should be monitored more closely whenever a CYP450 3A4 inducer is added to or withdrawn from therapy, and the buprenorphine dosage adjusted as necessary. Ambulatory patients should be made aware of the possibility of additive effects (e.g., drowsiness, dizziness, lightheadedness, confusion) when taking other CNS-active drugs and counseled to avoid activities requiring mental alertness until they know how these agents affect them."

[inga511]

I was on oxcarbazine for eight years. It's a really good drug. It's stabilizes mania. I just went off it in favor of topomax but I would recommend it-I had no side effects.