Your question is reproduced below:
In june 2008 operation ovarium cancer stage 4, thereafter 6 weeks, every week, carboplatin taxol chemo and thereafter was planned 6 times every 3 weeks carbotaxol chemo. But allergy on carboplatin after 3 times (in the cycle of 6 times, every 3 weeks), therefore they stopped chemo after the 5 th time. Scan was clear/completely okay in january 2009. they could have stopped then but went on with trying to give me the 4th, 5th and 6th. Now (beginning july 2009) cancer is back. CA125 is 98 (was 14).
Allergy starts directly after starting carboplatin. Few drops enough.
I have to decide. One hospital wants to start taxol carboplatin again.
The other hospital proposes to start celix in combination with other medicine (which ones I'll know this friday); they say that if cancer returns within 6 months after the last chemo, it's proven that this chemo doesn't work.
Which questions should I ask to get the information to be able to decide what to do?
What do you advice and think? Which are your ideas, way of thinking?
If possible, please answer me before friday 14 august 2009 (because I am going to talk about this on friday)
Thank you very much.
I need some clarification from you - When was the last time you took Carboplatin? If it was less than 6 months ago, your tumor is probably resistant to platinum compounds. If it was more than 6 months ago, your tumor may be sensitive to platinum compounds. One may use cisplatin if the patient is allergic to carboplatin (although some cross-allergy may occasionally be present).
Several approved second-line chemo drugs are approved for treatment of relapsed ovarian cancer.
All the best, and God Bless!
Apart from carboplatin and paclitaxel, there are several other drus that may be effective, for example, cisplatin, liposomal doxorubicin (Caelyx), gemcitabine (Gemzar), and melphalan (Alkaran). Also, there are some other agents like bevacizumab (Avastin), docetaxel (Taxotere), oral etoposide, weekly paclitaxel (nab paclitaxel or Abraxane), pemetrexed, and topotecan which may be used.