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4 month old Chronically rubbing his face

4 month old chronically ribs and scratches at his face. wakes him up at night and it is NOT dry skin. Ped and ER doctor both recommend 1/2 teaspoon of benadryl but there has to be an underlining issue.
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My 5 yr old son has had an incurable rash on his bottom for 2 years. I have tried everything. 3 pediatricians, pediatric dermatologist ...

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