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xolair

I have been using xolair for 2 years and it has been great as long as I receive the shots every 4 weeks. During the past 2 months I noticed small patches of hives the days before the shots are due. Now I am worried because I got my shots last week and I now have hives in the soles of my feet and palms. I am also taking zyrtec and syngular. Is it possible that at some point the mediction will stop working? Anyone with the same experience.? For a long time I got my life back, hope it will stay the same. Summer and hot temperatures are bad.
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