Hi, thanks for your post.
I have included the relevant figures in my previous post. I have also put the question up in the COPD general forum, but I also wanted the M.D's opinion on this forum, which has been very helpful.
I have spent the last year researching PFT's, COPD and in particular emphysema, and know a fair bit about the numbers.
I also read a lot of research articles, and have come across the anomalies and contradictions with hyperinflation and upper lobe emphysema, and the spirometry results.
I seem to fall into this category. The CT images are important to take into consideration with the PFT data.
Any input would be appreciated, thanks.
Thank you for your reply.
It is the inconsistency of the data which prompted me to ask the question. Your reply was both informative and intelligent, for which I thank you.
I am posting the following results for your information
Diffusion/gas transfer
Predicted Observed Observed Observed
Pre (absolute) Pre (% pred) Pre (SR)
Tlco (Hb) 8.78 2.94 33.54 -4.99
Tlco 8.78 2.97 33.85 -4.96
Va 5.63 5.67 100.83 ----
Kco (Hb) 1.56 0.52 33.27 ----
Kco 1.56 0.52 33.57 ----
Standardized residuals (SRs): +/-1 SR contain 90% of the reference population.
Severity scale for SRs: mild: 1.64 to 3.0 moderate 3.0 to 4.0 severe >4.0
Lung Volumes (Helium Dilution)
Predicted Observed Observed Observed
Pre (absolute) Pre (% pred) Pre (SR)
He-VC(L) 3.38 3.84 113.72 1.10
He-FRC(L) 2.93 4.95 169.02 4.04
He- RV(L) 2.00 2.98 149.42 2.82
He-TLC(L) 5.63 6.82 121.22 1.99
He-IC(L) 2.01 1.54 76.58. ----
He-ERV(L) 0.93 1.97 210.92 ----
RV/TLC(%) 37.33 43.71 117.09 1.09
It is the above gas transfer results which I think, show the damage my doctor refers to,along with the ct images, when he says that I have lost two thirds of my lung function.
My spirometry results included the following results:
Predicted Observed Observed Observed
Pre (absolute) Pre (% pred) Pre (SR)
FEV1(L) 2.88 2.43 84.22 -1.20
FVC{L) 3.37 4.11 121.94 1.22
FEV1/FVC(%) 78.83 59.09 74.96 -3.03
The ct images showed the extensive damage to the upper lobes, which looked diffuse.
I am being referred to one of the best pulmonary hospitals in the UK, but that could be many months away.
Many thanks again.
There appears to be some inconsistency with your data. Most notably is the declaration that you “have lost two thirds of my lung function” but have an “FEV1 of 84% of predicted.” While there is not always a good correlation between the amount of emphysematous lung and the reduction of airflow, as measured by the FEV1, it would be most unusual to have lost 2/3 of one’s lung function and still have normal airflow (FEV1 84% predicted). You should ask the pulmonary specialist for an explanation
Your request that the severity of your COPD be staged is reasonable and this could be done in accordance with internationally accepted standards, in either of two Guidelines for the Management of COPD: the GOLD standards or the ATS/ERS standards. Your lung doctor would be familiar with these standards. You should understand, however, that severity as judged by these standards, is not a criterion for operability.
The NETT study findings and subsequent observations established the criteria used today, for patient selection as being good candidates for surgery. Patients are selected according to the morphology of emphysema (upperlobe predominant versus other patterns; localized vs. diffuse), physiologic severity(FEV1, DLCO, Ppa), the patient’s fitness (6-minute/shuttle walk,), the patient’s perception/expectation regarding quality of life, and the presence of important co-morbidities such as coronary artery disease, pulmonary hypertension, sputum production, or ongoing tobacco abuse.
Your pattern of primarily upper lobe emphysema is considered to be the optimal pattern for LVRS. But this finding alone, without the following symptoms, is not an indication for surgery: in addition to the X-ray and CT Scan findings, there should be: abnormal PFT’s and low blood oxygen levels (at rest and with exercise), shortness of breath with exertion and low baseline exercise capacity . Persons with these characteristics are those most likely to achieve the greatest benefit from LVRS.
LVRS should be considered for patients only after they have received maximal medical therapy and have undergone pulmonary rehabilitation. Furthermore, a chest CT and cardiopulmonary exercise testing measuring maximum work load are required to determine if a patient is likely to benefit from the procedure. Once these objectives are fulfilled, LVRS can be offered to patients who have upper lobe predominant disease, as the procedure has been shown to improve symptoms, quality of life, exercise capacity, and lung function in this group.
Be advised, LVRS is risky and, in some instances lung function, symptoms and/or quality of life may worsen rather than improve.
My recommendation is that you seek a seek a 2nd opinion from a pulmonary specialist who has had much experience with COPD and this procedure and, if LVRS is ultimately deemed to be indicated, that the surgery be done by a surgeon with extensive experience at a major medical center. You have the right to request a report of the outcomes of previous surgery (of this type) performed by the surgeon chosen to do your surgery. And remember, there is no hurry to make this decision.
Good luck
I was wondering what your other numbers are? Such as your fev1/fvc and fvc and also tlc and dlco. All the numbers come together. The fev1 you posted is good. I know all the numbers along with your ct scan and clinical exam go together.