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May I get Info on Grade 2 Stage 2 liver disease please?
I’m 45 with Common Variable Immune Deficiency and Lyme Disease. Two liver biopsies have shown that I have autoimmune hepatitis that is Grade 2 Stage 2. I haven’t met with my liver transplant surgeon yet and I don’t know what this means as the nurse wanted the Surgeon to explain. Does anyone have information regarding this? They started me on steroids and immune suppressant meds in hopes to keep my body from continuing to attack my liver. Does anyone know prognosis of this? I’ve been a vegetarian for 33 years, have never smoked or done drugs and don’t drink alcohol if that helps with prognosis criteria. Any information is appreciated as not being given this is the worst part. I can handle most things as long as I know what I’m facing. Your help is greatly appreciated.
I think grade two might be what I am calling F2 or fibrosis score of 2.
Found this info
“Stage 2: Fibrosis of the Liver
Many times, symptoms of liver disease aren’t present until this stage or the next. In the fibrosis stage, damage or scarring from the first stage begins to block the normal blood flow of the liver. In this stage, the liver isn’t functioning correctly, but through treatment, it may be able to heal and prevent any further progression of the disease.”
Found this info
“Stage 2: Fibrosis of the Liver
Many times, symptoms of liver disease aren’t present until this stage or the next. In the fibrosis stage, damage or scarring from the first stage begins to block the normal blood flow of the liver. In this stage, the liver isn’t functioning correctly, but through treatment, it may be able to heal and prevent any further progression of the disease.”
We here are just patients the best source of information would be your doctor.
I’m not sure what exactly you mean by Grade 2 Stage 2.
When I was diagnosed with cirrhosis by liver biopsy I was told I have a fibrosis score of 4 or more commonly written as F4. There are five levels of fibrosis (liver scarring)
F0 no fibrosis
As far as stages of cirrhosis there are five stages
F0: no scarring (no fibrosis);
F1: minimal scarring;
F2: scarring has occurred and extends outside the liver area (significant fibrosis);
F3: fibrosis spreading and forming bridges with other fibrotic liver areas (severe fibrosis);
F4: cirrhosis or advanced scarring).
Once you have a diagnosis of F4 scarring aka liver cirrhosis there are 4 stages
Stage 1 is the earliest stage of cirrhosis and is characterized by the absence of two significant complications known as varices and ascites. Varices are dilated, ballooned veins. They are most often located in the lining of the esophagus and/or stomach. Acsites refers to an accumulation of fluid in the abdominal cavity. Both varices and ascites develop primarily because of obstructed blood flow through the liver, a condition known as portal hypertension. While people with stage 1 cirrhosis have extensive liver scarring, it is not severe enough to cause substantial portal hypertension and its complications.
Stage 1 cirrhosis is considered compensated cirrhosis. This means that despite extensive damage, the liver is not yet so severely scarred that clinically apparent signs of liver failure have developed. People with stage 1 cirrhosis generally do not experience many symptoms other than perhaps lack of energy and fatigue. Stage 1 cirrhosis is potentially reversible if the underlying cause of the cirrhosis is eliminated or cured.
Stage 2 Cirrhosis
Stage 2 cirrhosis is marked by the development of esophageal varices, due to worsening portal hypertension, but without the presence of ascites. While the development of esophageal varices indicates worsening cirrhosis and an increased risk of dying in the next 12 months, stage 2 cirrhosis is still considered compensated cirrhosis. There remains the potential for at least partial reversal of liver damage if the underlying cause of cirrhosis is eliminated or cured.
Stage 3 Cirrhosis
Stage 3 cirrhosis is marked by the development of ascites, with or without the presence of varices. The volume of ascites varies from being detectable only with imaging tests, such as abdominal ultrasound, to obvious bloating of the abdomen. The development of ascites signals worsening portal hypertension due to advancing liver scarring and deterioration of liver function. Stage 3 cirrhosis signals decompensated cirrhosis, meaning the liver is failing. Once decompensated cirrhosis develops, liver scarring is irreversible and evaluation for liver transplantation is generally recommended. A variety of signs and symptoms may be present with stage 3 cirrhosis, including:
pale and/or yellowish skin
weight loss and loss of appetite
shortness of breath
extreme fatigue
persistent, widespread itchiness
swelling of the feet, ankles and lower legs
wasting of the muscles of the arms and legs
Stage 4 Cirrhosis
The defining feature of stage 4 is gastrointestinal bleeding, usually from ruptured varices in the esophagus or stomach. This type of bleeding can be immediately life threatening if not controlled. Even if bleeding stops or is medically controlled, however, individuals with stage 4 cirrhosis still face a high risk of dying within 12 months. Persons with stage 4 cirrhosis have end-stage liver disease and urgent evaluation for possible liver transplantation is necessary. Signs and symptoms that might develop include those that may occur with stage 3 cirrhosis as well as others, such as:
confusion, personality changes and/or extreme sleepiness
hand tremors
reduced urination, which may indicate kidney failure
high fever, signalling infection of the abdominal cavity
I’m not sure what exactly you mean by Grade 2 Stage 2.
When I was diagnosed with cirrhosis by liver biopsy I was told I have a fibrosis score of 4 or more commonly written as F4. There are five levels of fibrosis (liver scarring)
F0 no fibrosis
As far as stages of cirrhosis there are five stages
F0: no scarring (no fibrosis);
F1: minimal scarring;
F2: scarring has occurred and extends outside the liver area (significant fibrosis);
F3: fibrosis spreading and forming bridges with other fibrotic liver areas (severe fibrosis);
F4: cirrhosis or advanced scarring).
Once you have a diagnosis of F4 scarring aka liver cirrhosis there are 4 stages
Stage 1 is the earliest stage of cirrhosis and is characterized by the absence of two significant complications known as varices and ascites. Varices are dilated, ballooned veins. They are most often located in the lining of the esophagus and/or stomach. Acsites refers to an accumulation of fluid in the abdominal cavity. Both varices and ascites develop primarily because of obstructed blood flow through the liver, a condition known as portal hypertension. While people with stage 1 cirrhosis have extensive liver scarring, it is not severe enough to cause substantial portal hypertension and its complications.
Stage 1 cirrhosis is considered compensated cirrhosis. This means that despite extensive damage, the liver is not yet so severely scarred that clinically apparent signs of liver failure have developed. People with stage 1 cirrhosis generally do not experience many symptoms other than perhaps lack of energy and fatigue. Stage 1 cirrhosis is potentially reversible if the underlying cause of the cirrhosis is eliminated or cured.
Stage 2 Cirrhosis
Stage 2 cirrhosis is marked by the development of esophageal varices, due to worsening portal hypertension, but without the presence of ascites. While the development of esophageal varices indicates worsening cirrhosis and an increased risk of dying in the next 12 months, stage 2 cirrhosis is still considered compensated cirrhosis. There remains the potential for at least partial reversal of liver damage if the underlying cause of cirrhosis is eliminated or cured.
Stage 3 Cirrhosis
Stage 3 cirrhosis is marked by the development of ascites, with or without the presence of varices. The volume of ascites varies from being detectable only with imaging tests, such as abdominal ultrasound, to obvious bloating of the abdomen. The development of ascites signals worsening portal hypertension due to advancing liver scarring and deterioration of liver function. Stage 3 cirrhosis signals decompensated cirrhosis, meaning the liver is failing. Once decompensated cirrhosis develops, liver scarring is irreversible and evaluation for liver transplantation is generally recommended. A variety of signs and symptoms may be present with stage 3 cirrhosis, including:
pale and/or yellowish skin
weight loss and loss of appetite
shortness of breath
extreme fatigue
persistent, widespread itchiness
swelling of the feet, ankles and lower legs
wasting of the muscles of the arms and legs
Stage 4 Cirrhosis
The defining feature of stage 4 is gastrointestinal bleeding, usually from ruptured varices in the esophagus or stomach. This type of bleeding can be immediately life threatening if not controlled. Even if bleeding stops or is medically controlled, however, individuals with stage 4 cirrhosis still face a high risk of dying within 12 months. Persons with stage 4 cirrhosis have end-stage liver disease and urgent evaluation for possible liver transplantation is necessary. Signs and symptoms that might develop include those that may occur with stage 3 cirrhosis as well as others, such as:
confusion, personality changes and/or extreme sleepiness
hand tremors
reduced urination, which may indicate kidney failure
high fever, signalling infection of the abdominal cavity
1 Comments
As far as prognosis well not really sure what your situation is at this moment. What tests have you had that said “Grade 2 Stage 2”? Have you had a liver biopsy, or a Fibroscan or a fibrosure tests?
Just in general terms for my situation as an example I was diagnosed with liver cirrhosis in January 2008. My cirrhosis was caused by being infected with hepatitis c for 37 yeas. Currently based on the definition of the stages I just posted above I am technically at stage 3 because I have some ascities. But I was treated and cured of hep c eliminating the cause of my liver disease so my prognosis is much improved. Three years later I still have cirrhosis but I feel fine and am now optimistic I won’t die from liver disease.
Your situation is different from mine but even people with F4 liver cirrhosiscn livevmany tears especially if they can remove the cause of their liver damage or diminish the effects of that condition. Your liver specialist is the only one who can properly diagnose your individual situation.
Just remember you don’t have an expiration date stamped on your body. There really isn’t any way to predict the course of your illness unless you are extremely ill. When your life expectancy is less than a year they can begin to maybe guess but beyond that there just is no way to predict. My wild guess is you will still be around for decades. Your doctor will know more
Just in general terms for my situation as an example I was diagnosed with liver cirrhosis in January 2008. My cirrhosis was caused by being infected with hepatitis c for 37 yeas. Currently based on the definition of the stages I just posted above I am technically at stage 3 because I have some ascities. But I was treated and cured of hep c eliminating the cause of my liver disease so my prognosis is much improved. Three years later I still have cirrhosis but I feel fine and am now optimistic I won’t die from liver disease.
Your situation is different from mine but even people with F4 liver cirrhosiscn livevmany tears especially if they can remove the cause of their liver damage or diminish the effects of that condition. Your liver specialist is the only one who can properly diagnose your individual situation.
Just remember you don’t have an expiration date stamped on your body. There really isn’t any way to predict the course of your illness unless you are extremely ill. When your life expectancy is less than a year they can begin to maybe guess but beyond that there just is no way to predict. My wild guess is you will still be around for decades. Your doctor will know more
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