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Stage 2 fibrosis, how many years will it takes to stage 3

I do not drink. Eat healthy, excercise and not overweight. Am taking vemlidy  am stage 2 fibrosis 8.1 kps. Will it takes years to go stage 3 ?
4 Responses
683231 tn?1467323017
With treating your hep b it is likely you will not progress further and could experience improvement to F1 or even F0
4 Comments
You mean it can be reverse? What medicine are you taking. And what s your condition?
I do not have hepatitis B. I had hepatitis C

You should ask about hepatitis B in that forum.

Yes liver damage can reverse if the cause of liver damage can be stopped.

I found this about hepatitis B from hepatitis B dot org

“Although those with chronic hepatitis B infection live with an increased risk of developing liver disease later in life, many should expect to live long and healthy lives. Someone with chronic hepatitis B should be seen by a liver specialist every six months, or more often as needed.”

Vemlidy is the best medicine currently available but it is very important you do not discontinue this medicine from what I am reading. Vemlidy can reduce hep B virus to below detectable levels. There is still some virus present Vemlidy is not a cure. But suppressing the virus prevent the virus from further harming your liver. With reduction of the virus your liver has a chance to heal.  From what I saw in the Fibroscan scale your score puts you just at the border of F1 and F2. You don’t have cirrhosis you have some amount of liver scarring.

I’ve had cirrhosis for 12 years but my hep c was cured almost 5 years ago. I wasn’t one of the lucky ones to see improvement in my Fibroscan score which is 29. But I have seen my platelet count improve slightly almost to normal levels. So even someone like me with a fibrosis score of F4 for a very long time can see improvement.

I also saw they are close to finding a cure for chronic hepatitis B so the longer you can hold off liver damage the better.
From the Japan Journal of epidemiology

“ The estimated carrier life expectancy is 71.8 years, as compared to 76.2 years among noncarriers”
From the World Health Organization:

“At the International Liver Congress (ILC) in Paris in April 2018, ICE-HBV members reported on encouraging developments towards an HBV cure. There are now almost 50 new anti-HBV and hepatitis D virus treatments being openly investigated, and 17 of these are already undergoing phase II clinical trials.

While a vaccine to prevent HBV exists, lifelong treatment is needed for those already chronically infected. Treatment helps keep HBV under control, but it is not a cure because it cannot completely clear HBV from infected cells. In addition, even with ongoing treatment, people are still at a higher risk of developing liver cancer, particularly those with underlying cirrhosis due to chronic HBV.

Recent scientific progress – and the momentum created by the discovery of a cure for hepatitis C virus (HCV) – has created a sense of renewed hope, as well as increased pressure, to find a cure for HBV, which affects more people and has a higher death rate than HCV.”
683231 tn?1467323017
Fibroscan results range from 2.5 kPa to 75 kPa. Between 90–95% of healthy people without liver disease will have a liver scarring measurement less then 7.0 kPa (median is 5.3 kPa).

Just for perspective, your score of 8.1 is only slightly above what a healthy person with zero liver disease would have.
9 Comments
My fibrosis scan also state no steatosis  median 232.
That would mean you do not have a fatty liver.

Your cause of liver injury is your hepatitis B infection.
Which my condition only stage 2, do you think i can wait for treatment . Have the vemlidy medicine but did not take it yet scared of side effects, but doctor want me to take it now? Do you think i can wait  until i be stage 3 , that could be in years ??
Get treated as soon as you can to prevent further damage and allow your liver to heal.

Do not wait for further damage to occur. Imagine the virus is a sledge hammer beating on your liver every hour of every day wouldn’t you want to stop that as soon as possible?

Yes could be years or never but why allow the virus cause additional damage. I recommend you follow your doctors recommendations.
I tried to treat my hep c five times. Three with the old self administered shots of interferon three times a week for six months. The side effects were pretty miserable and it was only about a 30% chance of working. I treated two more times with a better interferon only one shot a week still for six months and with other medicines that mad you feel very weak and tired. Those three treatments did not work and I watched my liver go from F1, to five years later F2, and five years later to F3. Finally on my fourth liver biopsy I was F4 liver cirrhosis.

Believe me it’s much better to risk maybe side effects than getting up to advanced liver disease and approaching liver cirrhosis and possible liver failure. You don’t know if it would take 5 years like me might be faster and being sicker your body would be less able to tolerate treatment
Thank you very much for reply and advice, it help me ease my mind, because I a renal cyst that is non cancerous , and could that cyst cause pain that I have on my lower right back? Afraid taking medicine could worsen my kidney..
I’m not a medical person I’m just a patient with liver disease I only know what I can google. These are important potentially life altering decisions I urge you to discuss your concerns with your medical personal physician.

In my non expert layman’s opinion I think you should follow the advice your doctor has given you and treat your hep B now. I’m more worried about the consequences for your liver if you fail to treat your hep B than a renal cyst. In fact having liver disease can effect more than just your liver. Liver disease can effect your kidneys (hepto-renal syndrome) and your heart (Cardio-hepatic syndrome).

“Renal cysts are sacs of fluid that form in the kidneys. They are usually characterized as "simple" cysts, meaning they have a thin wall and contain water-like fluid. Renal cysts become fairly common as people age and usually do not cause symptoms or harm.”

I said it could be years or it could be never but it could also be sooner that your fibrosis increases to level F3 borderline liver cirrhosis. It took me five years to go from F2 to F3 and another five to go from F3 to F4 liver cirrhosis. Do you want to have liver cirrhosis in ten years maybe less maybe more there is no way to know. Why take that risk? please follow your doctors advice. If unsure get a second opinion from another doctor.
Thank you for all your advice. Since just newly diagnosed with hepb, my mind was so confuse and scared, but with your answers, it has calm my mind , thank you very much
683231 tn?1467323017
“ Liver fibrosis is the final result of most types of chronic liver injury. Most habits and events that injure the liver will lead to a fibrotic liver. ... There is clear evidence, based on findings from repeat biopsy, that mild to moderate fibrosis is reversible.”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995196/
7 Comments
I had a 17 in fibroscan is that mild or moderate enough to reverse?  Or is it too late or too high?

I really would wish I could go back in time and reverse this condition.

Doctors in my area are few and not good. I went twice and the question of the moment “are you a liver transplant candidate?” She asked me in both appointments.  Am I?

I am note sure what cause my liver damage... I do not drink I don’t exercise I am 25 lbs over weight (plus size) I do a lot of fast food but I am trying to control that.  I do not have hepatitis.  Fatty liver?

I have traveled a lot in the past, and did see some   Antibodies for hepatitis A once, long time ago, when I started having problems with the liver.

Anyway I will visit my gastro soon, I will ask him too.
There have been some with F4  cirrhosis who have regressed to F3 and even F2. For myself I haven’t seen a change In my Fibroscan score results since I was cured of hepatitis C five years ago. But my platelets did improve from about 85 to now around 125 so getting close to normal range.

The important thing is stopping whatever is causing your liver damage this will give your liver an opportunity to heal and prevent future damage.
My Fibroscan scores have been 27, one year after treatment it was 33 and four years after it was 29. I figure that really it isn’t any change as the devise is not that precise.
Do you think, I needto get hep a vaccine or hep b vaccine? Or it will do anything since i am chronic hep b positive
A vaccine is to prevent infection. So having  the hepatitis B would serve no purpose. As far as being vaccinated to prevent hepatitis A in my non medical opinion that would be a good idea. As you are already infected with hepatitis B you can little afford another infection that attacks the liver.  However, this question is best asked of your personal physician.

In case you are curious there is currently no vaccine for hepatitis C.
Hi Zairepr I missed a couple of your questions.

You should be under the care of a hepatologist. General practitioner doctors  are not equipped to follow a patient with advanced liver disease. Depending on the cause of your liver disease a score of 17 equates to either F3 advanced fibrosis or F4 liver cirrhosis.

Patients are placed on the liver transplant list based on their MELD score. The MELD is a composite score based on several of your blood tests.

MELD stands for "model for end-stage liver disease." (Doctors use a different system, called PELD, for children younger than 12.) A MELD score is a number that ranges from 6 to 40, based on lab tests. It ranks your degree of sickness, which shows how much you need a liver transplant.

MELD uses the patient's values for serum bilirubin, serum creatinine, and the international normalized ratio for prothrombin time (INR) to predict survival.

If you know those test results you can look up a MELD score calculator and input your data and see for yourself what your MELD score is. Most transplant centers require a MELD of at least 25 to be listed and most transplants occur with a MELD around 30.

You would have to be working with a hepatologist associated with a liver transplant center to be listed. I very much doubt you are a candidate at this point and are definitely not on the list you would be very aware of that if you were there is a very complex processes to be placed on the list.

Yes having fatty liver can cause liver disease due to fatty liver however there are other causes of liver disease.


Liver disease has many causes.

Infection

Parasites and viruses can infect the liver, causing inflammation that reduces liver function. The viruses that cause liver damage can be spread through blood or semen, contaminated food or water, or close contact with a person who is infected. The most common types of liver infection are hepatitis viruses, including:

Hepatitis A
Hepatitis B
Hepatitis C
Immune system abnormality

Diseases in which your immune system attacks certain parts of your body (autoimmune) can affect your liver. Examples of autoimmune liver diseases include:

Autoimmune hepatitis
Primary biliary cirrhosis
Primary sclerosing cholangitis
Genetics

An abnormal gene inherited from one or both of your parents can cause various substances to build up in your liver, resulting in liver damage. Genetic liver diseases include:

Hemochromatosis
Hyperoxaluria and oxalosis
Wilson's disease
Alpha-1 antitrypsin deficiency
Cancer and other growths

Examples include:

Liver cancer
Bile duct cancer
Liver adenoma
Other

Additional, common causes of liver disease include:

Chronic alcohol abuse
Fat accumulating in the liver (nonalcoholic fatty liver disease)

Hope this info helps
Thank you for your very good advise & information.
Avatar universal
It took me 17 years to go from no stage to stage 4.  Do what ever you can to reverse your condition.

I would assume it is different for everyone

Try to find what is causing it and try to fix it

It is not a nice feeling in stage 4 with all the other health conditions that you get later in life.
2 Comments
What is your condition? Are you hepb chronic? And what medicine are you one to treat it?
My condition is liver cirrhosis stage 4.  It is very recent.     I have visited the doctors twice.

No I am not Hep b nor c.  My doctor had me vaccine for hep b right away

I take no medicine for liver cirrhosis
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