Avatar universal

Monoclonal Antibodies COVID 19

My mom has been having trouble with COVID 19 and went to the ER to get checked out this saturday. She is 67 and 87 Lbs and a very small person (4 foot something). She's had her symptoms since the 20th and the ER doc said that 'you are technically out of the window but I can approve the antibodies". She's not vaccinated.

There was argument with the hospital as they wouldn't initially do it as she'd be > 10 days but they eventually did it. She's now scheduled and it will be 15 or 16 days since symptoms when getting this.

Reading the paperwork on the infusion it says you should be at least 88 lbs and symptoms < 10 days.

* Why do they have the 10 day limit? Is it just to ensure consistency of the study, rationing, or is it a legitimate waste or harmful to get it after 10 days. I would think it can help her somewhat.
* Is it harmful to get it if under 88 lbs?
2 Responses
Sort by: Helpful Oldest Newest
134578 tn?1614729226
Ask the doctor for a correct infusion for someone of her weight, or (because it's possible he doesn' know), contact the company that wrote the paperwork you have, which I assume is the company that developed it. It seems like it would still do some good even if it has been more than ten days.
Helpful - 0
Avatar universal
The reason is that in the studies that have been done so far the data appears to show it only helps those who get it early after getting covid.  After that the data didn't look so good.  I'm not sure it's a known harm thing, but there are a lot of possible unknown harms in meds that haven't been used for a long time.  That isn't just true for drugs only approved for emergency use, but also  for drugs that go through the full approval.  I'm assuming both of the monoclonal antibodies in existence will be fully approved because they work really well.  But because it does only have emergency approval, docs are going to be more reluctant to use them otherwise because, frankly, nobody from the company is yet selling it to them for things the FDA didn't approve it be used for.  They will, just wait.  But we do have a very well known example of someone who did get one of them later in the disease's procession, and that was former President Trump, whose life was very likely saved by it.  He was out of the window, I believe.  Do see if you can find out if safety is a concern and if dosage varies for smaller people, but I'm guessing the company won't tell you anything and I don't know if your doctor is likely to have seen any data.  You might be better contacting CDC or NIH, but again, if you do, by the time you find out it may be too late.  I think the reality is, the perfect isn't available, and your doc is going to have to make a decision.  
Helpful - 0
And the fact that your doctor did give it to you to give to her makes it sound like the doc did make the decision. I think it sounds like an issue where the drug company didn't think it would help much after the 10-day period, rather than it would be somehow harmful after 10 days.
Or, I guess, you said they have scheduled the infusion. (I couldn't really imagine that the doctor handed it to you, but something about you reading the paperwork had given me the mental image that you had opened the packet and were reading the instructions.) Since she is going to be under medical care during the infusion, I'm sure your doctor can do his best guess as to why it says less than ten days, and especially adjust the dose if necessary due to her small size.
Have an Answer?

You are reading content posted in the Coronavirus Community

Didn't find the answer you were looking for?
Ask a question
Popular Resources
Learn more with our FAQ on Ebola.
Herpes sores blister, then burst, scab and heal.
Herpes spreads by oral, vaginal and anal sex.
STIs are the most common cause of genital sores.
Condoms are the most effective way to prevent HIV and STDs.
PrEP is used by people with high risk to prevent HIV infection.