Yes, anything that affects your hormones can have profound emotional effects. Before anyone goes on antidepressants they should have a doctor who not only can but will eliminate all possible physiological causes before deciding it's mental illness. Doctors are also not the specialists in this area, psychiatrists are. And don't miss pills -- you can go into withdrawal and have some unpleasant days when you do that. What I'd do is find a good psychiatrist and taper slowly off the Zoloft before you try something else -- you need to do this slowly to do it the safest way. I say this because it isn't working, and it's odd your doctor is keeping you on a med that isn't working. That's why I don't think your doctor knows a lot about this, and that makes sense because regular docs have no special training in mental illness. But I would get your doctor or another one if this one doesn't appeal to you at this point to eliminate all possible physiological effects, and you should definitely broach the hormone possibility. And once you're off the drug safely, did you ever try therapy before going on drugs? That's usually how it's done, providing no physiological cause is found. And once you're off the drug, you can also do an experiment -- try stopping the hormones and see if you feel better. Remember, stop slowly, at a pace that suits you. Good luck.