Does Wellbutrin stop working for my depression?

[SUNDRY]

I began taking Wellbutrin XR 150mg at the beginning of this year...it has been very helpful...the biggest change was that I was able to get out of bed in the mornings after a stint of depression...other than that my general wellbeing improved as well...it was actually like living on cloud 9...i couldn't believe how drastically my life changed in a positive direction after such dark times...

Also of note is that my sex drive increased...while I've only been with a single partner this year (and we only saw each other for about three weeks)...our intimacy was more fulfilling than most of my past encounters...she benefit from the wellbutrin in these encounters as well...

All of a sudden...I no longer feel the effects...I'm not kidding...last week they started to dissipate...today it's culminated in this weird day where I've felt more negative emotions than I have all year and there is absolutely no other explanation I can conjure...(no unique triggers this last week...NONE)...I feel wrong wrong wrong...

My nurse practitioner said that it doesn't diminish in efficacy...I'm still on the same dosage, but earlier this week I took two pills in the morning to see if there would be a change...and it still didn't feel the same...

If anyone could share experiences or advice! I'd especially appreciate anyone who has personal long-term experience with wellbutrin. I'd also love to hear from someone who has had similar changes in their sex drive. Anyone who has had a significant other on this medication or a child, I'd also welcome any comment.

Thank you all!

[DepressedInTexas]

I have been on Wellbutrin XR 300mg for 2 years. It worked well for me on my severe crying spells.  It definitely decreased my libido (although that was already an issue due to my major depressive disorder).  I would definitely recommend going up to 300mg.  I didnt have any crazy side effects on this dosage.

[Paxiled]

Not to diminish nurse practitioners, but they aren't the best informed people out there.  They have very little training and pretty much none in psychology.  All drugs can stop working.  We in the suffering biz call it pooping out.  Most of us have had it happen.  When it does, sometimes what you need is a higher dose.  Sometimes it just stops working and you need to try something else.  Sometimes it's not the drug at all, you just have a bad day or week because no medication cures depression, they just make it less bothersome.  Some people do get cured in therapy, but we don't know what causes depression yet and so we can't cure it with medication.  Very few things in life are cured by medication -- mostly they just tamp down symptoms.  And they can all stop working if we're unlucky and our bodies just get too used to it.