By now if nothing has happened it won't. Serotonin syndrome is very rare, and 5-HTP is only theoretically a culprit -- it's just playing it safe, not something that's happened much if at all. Keep in mind that 5-HTP will only make more serotonin if your body needs it, that most serotonin in the body is in the digestive system and the blood vessels and muscles and the body will direct it to where it's needed; if it's not needed the body breaks it down and evacuates it. Of course, the drug interferes with this breakdown process a bit, but Remeron targets more than just serotonin so it isn't as strong in that area as an ssri or an snri. You're safe. Just don't do it again -- if you want to try natural remedies you have to stop the antidepressants that duplicate effects on neurotransmitters. Good luck.