Actually, taking two meds at once if you're just starting out makes no sense. Why take two meds if one will do? Why fact two sets of side effects when you can just face one? Personally, I'd stick with the Lexapro and skip the wellbutrin. The main reason for combining the two is if you get certain side effects from ssris, such as sexual dysunction and weight gain. Here's one problem: wellbutrin is a very stimulating antidepressant. Lexapro affects people differently -- ssris are usually sedating, but they can affect some people by being too stimulating. Too much stimulation can cause anxiety. But if you try two meds when you're starting out, you'll never know if that med works or not or if just one med does the trick. That's my two cents worth.