Avatar universal

REM sweats with Effexor?

I've been taking Effexor XR (75 mg, 1 daily in morning) for about 7 months, and I love it, but I'm concerned about a possible side effect. For the past 6 months, I have been getting terrible night-sweats that appear to be limited to REM sleep. I am not normally a sweater - even when I work out I don't sweat this much.

I believe that the sweats are limited to REM sleep for several reasons: the sweating always wakes me up, and I am always in the middle of a dream when I wake. As long as I am in the midst of a dream, I sweat (also happens if I start to drift off and have a light-sleep dream). Also, my sweating wakes my husband -- which is sad for him, but useful for corroboration. He says that while I sweat, my eyes tend to move rapidly under the lids, that I have muscle tone (unlike deep sleep, which has little to no muscle tone), and that I am somewhat responsive to outside stimuli. All this suggests to me that I am in REM sleep. The rest of the time - no sweating.

I don't think that this is related to anxiety, as I get this symptom even if I am having happy or funny dreams. Also, there seems to be no difference in quantity of sweat based on dream content - nightmares are pretty equal in volume to happy dreams. I also don't think it's related to room temp, as I have tried setting the temp at anything from 60F to 80F, and the sweats are pretty consistent across trials.

I am not certain this is related to the Effexor (it could simply be related to diet changes, the fact that I started smoking again ~6 months ago, or the fact that I'm in my last semester of grad school), but the symptoms started shortly after reaching consistent Effexor blood serum levels (btw - I'm getting my degree in neuropsych, so I've been watching all this closely from a clinical point of view).

One thought is that the Effexor could be interacting with the nicotine - is this possible/probable?

This sweating is really disgusting (and dehydrating). Please, any thoughts/advice you have would be appreciated.
6 Responses
459689 tn?1276570143
It IS the SSRI and dont let a doc tell you it is anxiety (they love that one). I am stopping Zoloft for that and many other reasons. The insomnia and too much evergy effect.

It is not pleasant to wake up several times during the night and feel that cold wet chill, it is horrible in fact. I often had to change the jammies and then dont have a prayer of going back to sleep. I had none of this with the other and only SSRI I ever took and I  have just switched back. With doc supervision of course. Doc supervision seems to mean I do all the research and they just nod and write the prescription, and that applies to several psychiatrist's DO,s Md,s you name it. They are lazy over burdened and so on.

I have found that it is up to ME to figure this stuff out and explain it to the best of my ability to the quacks.

From your very thorough well thought out post, it sounds like you are doing the same. keep on keepin on.

I have been dealing with excessive night sweats for over 20 years. Before,during and after menopause..during and after the use of many types of SSRI and SNRI's. Nothing takes away the dripping, cold, sweating. Years ago my thyroid was tested. It checked out ok so they gave up on helping me find the root cause and put an end to this way of living. Being on antidepressants for anxiety and depression makes me sweat and because this, it just increases my anxiety and depression for lack of quality sleep, although I do not have a problem falling asleep or staying asleep, as long as I'm not sweating. but i sweat every single night, changing clothes mostly 3 times a night. I am on disability and don't have a caregiver to help me with laundry and changing sheets, so I believe my best option is to stop all antidepressants!
I don't know which ones you're taking.  I've had this problem with only two of them, which are very similar meds with one being derived from the other, Lexapro and Celexa, but it had never happened to me with any other antidepressant.  It's definitely a thing, but again, not necessarily with all antidepressants.  I dealt with it by taking three showers a day.  And you know what?  Even after stopping the meds, I still have to take those three showers a day because if you've been on these meds for a long time the side effects don't all necessarily go away.  
Avatar universal
While on Effexor XR  I use to wake up soaking wet, I thought maybe I was going through the change at 42, but the doctors said no. After weening off for 5 weeks and being drug free for 1 week, I have not woke up not once soaking wet.  Although if I sleep more than 3 hours at night it 's a miracle. I hadn't thought about that til I read your comment.  Thanks, I guess that's the first good thing that has happened since I stopped this awful medication. ( Although, I didn't think it was awful 2 years ago when I first started taking it)   Aliwann
375688 tn?1348459116
It seems like I've been suffering with night sweats for ever. Some times are worst than others. I can relate to the REM correlation. The longer I sleep the worse the sweating is. If I just sleep a couple of hours a hardly sweat at all. But if I sleep more than 8 hours I can guarantee My sheets will be soaking wet. I mention this to my psychiatrist and see said I should have my thyroid function check. My general practitioner checked it 2 months ago and increase my Synthroid. I am due to have it rechecked again. I've been on Effexor and Synthroid for years. I was just looking at the known side effects of Effexor XR and sweating is high on the list. Another thing side effect is abnormal dreams which goes along with your REM observation. While I don't remember any "bad" dreams I have had quite a few abnormally vivid dreams, especially when I sleep longer than 8 hours. Have you experienced and "abnormal" dreams?

Sometimes I take Effexor XR and sometimes I take generic Effexor. Now that I think about it I believe the night sweats diminish when I go to generic Effexor. At one time I was on 375 mg of Effexor XL but dropped it down to 300 mg because my Medicare Drug plan would only pay for two pills a day. I was thinking of see if the psychiatrist would be ok with reducing my dose. The problem is with the Drug Plan only paying for two pills a day and the Effexor XR coming only in 75 and 150 mg doses I would have to half the dose to 150 mg and I don't know if that would be an effective dose for me. When on the generic Effexor the Drug Plan doesn't limit the dose and its cheap. But when I was on 375 mg of generic it didn't seem to work as well and the 300 mg of the XL.

Between the Doctors only going by trial and error, on what then drug companies tell them, the sorry state of mental health research in neuro-pharmacology; and the medical insurance companies dictating what drug dose one can receive, its really makes me want to just give up.

Note to any insurance companies that might be reading. You might want to reconsider you drug policies. I've left instructions for my family to sue the sh*t out of you if something related to my mental illness happens to me. And I am not one to just sue because that's what everyone else does, but these policies are like practicing medicine without a licence and should warrant criminal penalties. But unfortunately civil actions are all that we can rely on.

Avatar universal
While I don't remember any "bad" dreams I have had quite a few abnormally vivid dreams, especially when I sleep longer than 8 hours. Have you experienced and "abnormal" dreams?

My dreams have always been abnormally vivid. I was a lucid dreamer for most of my life, until I reached adulthood, when I developed problems with insomnia. Since starting Effexor, I finally sleep again at night. And the dreams are just as wacky as ever (I've been known to wake up laughing at them, both as a teen and now that I sleep again.) My guess is that the Effexor fixed my insomnia because humans have a day/night schedule similar to plants. During the day our happy/content feelings are regulated by serotonin, and at night serotonin converts into melanine which induces sleep. Not having enough serotonin in my synapses meant that I was depressed during the day, and had nothing to metabolize at night to make me sleep. Effexor doesn't increase actual serotonin production, but it slows down the re-absorption, which has a similar effect - I now have enough laying around for healthy neuro function.

I can actually deal with the sweats -- it's just that its completely disgusting. I'm actually thinking of mounting a quiet box fan in the box springs on my side of the bed to keep air moving under the mattress - hopefully that will speed evaporation. yuck.

I agree with you about the hit-and-miss nature of prescriptions these days. Doctors don't seem to prescribe based on symptoms anymore, so much as they allow the drug reps to dictate the drug of the month. I used to be a member of my doctor's "drug of the month club" (so to speak) until I got tired of it and decided to start dictating to her how my treatment would go. She was upset at first, but I pointed out that my education in the neuro field was more extensive than hers, and that she wasn't the only doctor in town. I felt like such an intellectual bully, but it worked. I regulate my own dosage now and tell her what other meds (for my endometriosis and allergies) will or will not interfere with the effexor.

I think, Tom, the best you can do is take an active role in your treatment -- which it sounds like you're doing! If doctors don't recommend tests, insist on them. You can actually calculate brain serotonin levels based on a blood sample from your arm. Red blood cells have serotonin receptors, and the number of receptors on the blood cell reflect the amount of serotonin available in your body (including your synapses).

Know that SNRIs are both serotonin and norepinepherine (NE) reuptake inhibitors. NE increases alertness and energy levels, but at levels that are too high it can cause paranoia. The level depends on the person. For me, I have to stay at a fairly low dose of Effexor because I already have problems with hypervigilance, cranking my NE too much higher makes me psychotically paranoid. But I do need the slight NE boost. Sometimes the process is trial and error, because everyone's body chemistry is different, and you need to figure out what works for you. But it shouldn't take more than about 6 months to get even the most confusing/complicated cases sorted out (because most modern SSRIs reach stable blood serum levels in a week, and within the first 1-1.5 months your body should fully adjust).

Ok, this was a really long-winded post, so I'm going to stop now.

I'm really grateful to know that there are other people out there with the night sweats. And to know that it's probably not an interaction with the nicotine. I'm not really interested in quitting smoking right now (want to finish my @$^@! degree first, and I need the smokes for that :)

If anyone has come up with an environmental solution to the sweats (like a fan in the box springs), please let me know! I'll bet we could all use something like that ;) And I'd love to know if it worked for you
477048 tn?1215567947
For me I've taken the effexor too and even got up to 200 mg a day and love it,although I've never had any side affects other than a headache and dizziness...Im sure the reason for your sweats is not because of the niccoteen..I'm a smoker too..I think what you could have is an allergic reaction to the medication..Not sure though! I'de tell your doctor about it asap...
Avatar universal
Well it must be the Effexor,  I wake up in the middle of the night, sometimes twice to change my clothes they are soaking wet.  Especially after having a dream.  The bed is soaked to no end.  I feel like I went swimming and then jumped into the bed without drying.  Glad to know that it is not me thought just the medication.  Hopefully will be off of it soon.  I was taking anxiety pills and another antidepressant.  I have started taking zeal for life supplements.  Expensive, but if you want to quit pills this is the way to go.  Love it.... Maybe soon the night sweats will be gone.
Hope all goes well for everyone else.  May God richly bless each of you.
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