First of all, you have a lot of can'ts in your message, and if you believe you can't, you can't. Meditation, for example, isn't something you can or can't do -- whatever the experience is, that's the experience. When we get to expecting something from the meditation, and I've developed that problem after years of wonderful meditations, then it seems the meditation isn't doing anything. More likely, it just means you need to try a different form of meditation and need to stop having expectations, but that's easy to say and very hard to do, especially for those of us in Western societies. But if you're judging your meditation, you're doing it wrong and you need to see a spiritual teacher, not a psychologist to teach you meditation. You don't have to adopt the particular spiritual path, but you'll learn what meditation actually is, which isn't a relaxation technique as much as a way of watching how you think. As I say, I now have the same problem you have, and I hate it -- I relied a lot on meditation. In my case, and I think in yours, the problem may be quitting drugs, not taking them. Withdrawal, especially as often as you've done it, can be impossible for the brain to get over if you've been on antidepressants a long time. Don't know how many people are affected by this, but estimates are about 10-15% without any solid data because nobody will pay for it. In your case, you have insomnia, and one of the biggest problems people have with long withdrawals, or protracted withdrawals as they're called, is insomnia, so you've compounded your problem by quitting your drug abruptly and putting yourself into a profound withdrawal. I also don't quite understand the anti-histamine thing -- the drug you quit wasn't an anti-histamine, it's a tricyclic antidepressant, a class that preceded the discovery of ssris. They are notorious for causing constipation -- I was on imipramine for a few years until it stopped working and I had it. You compensate for it by using fiber and eating a diet that is easier on your digestive system if you want to stay on the drug. Seroquel has a very controversial history, as do some of the other drugs you've been on. It was illegally marketed for a lot of things, including sleep, but it only helps you sleep as an unwanted side effect of the medication. Doctors often put people on drugs that are sedating as sleep aids, but the sedation is not a wanted effect of the drug -- it's a side effect. Meanwhile, the drug is doing as well whatever it was created to do, and often this isn't something your system needs or wants. Using benzos for sleep is also a problem, as they are addictive, very hard to stop taking, and interfere with REM sleep. Ideally, we all want to learn to sleep naturally, not with the aid of a drug taken regularly, because eventually the drug will bite us back. I don't have a clue how to help you do that other than the usual tropes -- exercise yourself into exhaustion, stay busy, try natural remedies that don't cause rebound insomnia such as melatonin or homeopathy. Try hypnosis, try anything. But here's what I can tell you from my own experience -- anxiety never gave me regular insomnia, but a permanent withdrawal from Paxil caused by a quack psychiatrist destroyed my system and I haven't had a complete night's sleep in 12 years. I hate it. I don't know how to recover from it. Which is why I would encourage you, given how hard your withdrawal is going, to consider going back on the drug and tapering off as you should have to at least get rid of this one problem so it will stop.