Hi. Hm, to be really honest, I'm not sure about this. Do you generally have sleep issues? I notice that when I'm sleep deprived, get too much sleep, etc. that my face looks 'different' if you will. Does it stay looking different or is this just when you get up? I do know that with mirtazapine you are supposed to alert your doctor immediately if you have swelling of the hands or feet. https://www.webmd.com/drugs/2/drug-13706-4047/mirtazapine-oral/mirtazapine-oral/details/list-sideeffects That's a huge list but remember that while rare can happen, that if something is listed as rare, it likely won't.