I have suffered ith skin lesions for about two yrs. I had my primary doctor say it was erythma multiforme and sent me to a dermatoligist, who said it was by looking at it. I then have it return and a new dermatoigist thought it was hives. they did a biopsy and it came back as hives,she said I might have the two things going on. I stayed on valtrex the first time for six months,with no help. the second round two different allergy pills,that did calm it down.I had abreif period that I thought it stooped. I have know the ones that look like erythma multiforme. They start out as an itchy bump that start having a place that looks like a sting would have been,it then start spreading into a round ring that grows very big and blisters. The first time I had about eight of these on my hands. The one on my pinky had a very huge blister form. IThe lesions stay for for months, same spot . I wanted to know do hives form lesions that look like erythma multiforme and stay their for months growing? I thought hives come up and then fade not leaving sores. I can see that they might come and go while new ones come up,but they would fade.Can this be hive? What can I do to make them go away. I also want to say that I have neurapthy. They thought on the beginning it was Ms, and I have been checked fo lupus and you name it.Could it just be my autoammune system? I know you ca't diagnose me,but I would like to here your opinion.