We live in Northern Nevada at 5000 feet of elevation and in high desert. I find I can travel to 100 feet above sea level in California, where it's moister, but that traveling to Southern Nevada (Vegas, etc) is pure agony.
I have pretty well controlled diabetes. My last A1c was 6.1 and I eat carefully and while I'm heavy, I'm losing weight. (A dress size in 2 months)
I have a moderate amount of osteoarthritis in my knee, but the pain I experience with travels to the desert in the south at lower eleveation includes hands, feet, hips, knees and excrutiating. A soak in a hot tub often relieves it substantially.
My maternal side of the family has a long history of rheumatoid arthritis. Do I need to get tested again?