can nexium stop working?

[joi]

I have been on nexium for almost 3 months and it was working great..before I had a constant lump in my throat and my food would comeup when I bend over..the nexium worked well but last week I came down w/ a virus and was vomiting constantly for 24 hrs ..since then I have had the reflux again and also a heaviness around the upper right rib area..can the nexium stop working..I am taking 40 mg 1x a day..

[Kevin Pho, MD]

Hello, thanks for asking your question.

I am not aware that a PPI can suddenly stop working.  However, there are cases where GERD are refractory to optimal PPI treatment.  For intance, GERD can "breakthrough" optimal PPI therapy.  Up to 70 percent of patients taking PPIs twice daily will have periods of gastric pH <4 lasting for more than 60 minutes, particularly at night. Nocturnal acid breakthrough may be responsible for the majority of patients with refractory GERD.

Patients with increased gastric acid production, defined as basal acid output above 10 meq/h, may be predisposed to refractory GERD. Although some of these patients have the Zollinger-Ellison syndrome, others have no apparent cause. Thus, gastric acid hypersecretion should be considered in patients who are refractory to standard or relatively high-dose PPI therapy.

Patients who have heartburn without endoscopic or pH evidence of GERD may have esophageal hypersensitivity to physiologic acid reflux. Patients with functional bowel diseases (such as irritable bowel syndrome, dyspepsia, or globus sensation) may have clinical features that overlap and can be confused with GERD.  Other diseases that should be considered are achalasia, esophageal cancer, esophageal stricture, other causes of esophagitis, and gastric stasis.

So the bottom line is, if you are still experiencing symptoms of GERD while on optimal PPI therapy, you should promptly see a physician to rule out any "non-GERD" causes of your symptoms.

Thanks,
Kevin, M.D.

[mehranny]

A related discussion, Severe Reflux - for 5 years was started.

[jamies]

I suffered from GERD for 2 years.  I was then prescirbed to Nexium and it worked for approximately 6 months.  Afterward, it did not work at all, and the symptoms came back as they were before I started taking the medication.  I heard that going off of it for 2-3 weeks, then starting my prescription again, may make it work as it did.  Has anyone experienced this?

[marygold]

I think that Nexium works. I've been on Nexium for over a year now, 40mg, once daily, and while I still find that it doesn't cure my GERD, it does bring it down to a level that I can tolerate. Nothing else worked for me; if anything, each one made me worse. One doctor told me that I'd be on it for the rest of my life. Yes, the GERD is still there, but it helps to lessen the severity, instead of masking it. Masking it is when it makes you feel better without doing anything about the condition. Nexium does something about the condition (to different degrees for different people) and that's what makes people feel better, in some cases. Granted, it doesn't work for everyone, but I don't see how it can suddenly stop working.

[Suziepie]

I don't think Nexium works at all.  It might temporarily mask a problem, but eventually the problem will resurface.

[weiwei]

I took Protonix for 4 months, having some sense of light-headedness. My doctor told me it couldn't caused by Protonix.
I believe what she said and keeps taking Protonix and keep having dizzy problem.

Finally I tried Nexium, another doctor let me try. It is great. I don't feel dizzy any more. Hope it can cure my Gerd soon too.