Dog taking Galliprant and Metronidazole

[Ipprocess]

My 10 year old blue healer had a bad reaction to Clavomox that was given to her for a leg cut. After about 5 days of taking this, she was barely alive (we watched her get very lethargic but she would get better during the day and then go downhill at night). We took her to a new vet where she was put on IVs and eventually got mostly better but a week later was very weak and was limping pretty bad. The vet said she had arthritis and put her on Gallaprant saying her blood work indicted some a low level of pancreatitis so shouldn't get a steroid. After 2 weeks on this and behaving OK (not great but better), she again became very lethargic and didn't want to eat. Back to the vet for more IVs and blood work. This time she had an ultrasound which showed some biliary sludge. So she was given antibiotics (metronidazole), a medicine to help her potential ulcer (Sucralfate), as well as a medicine to help dissolve the sludge (Ursodiol). We were also told to keep her on Galliprant. She ate slightly for the first couple of days and is now not eating anything. The vet has now said to keep her on all of the meds except Galliprant and to come in for an anti-nausea as her belly might be upset from the antibiotic causing her to not want to eat. Has anyone had any experience with Galliprant and/or Metronidazole? Taking them at the same time?

[ginger899]

No I am sorry I don't have direct experience of combining Metronidazole and Galliprant. But Galliprant is basically an NSAID (non steroidal anti inflammatory) So I can't see any obvious reason why that shouldn't be prescribed alongside an antibiotic.
The thing is though, Galliprant can also cause GI upsets: nausea, loss of appetite, sometimes loose bowel movements.
So it seems she has two medicines going on which can cause upset tummy, as side effects.
Check for black stools, and be watchful that if for instance she vomits, there is no blood in it. Those are the more severe side effects of an NSAID. They rarely occur, but are possible.

I would definitely try her with tasty but easy to digest food. NOT kibble -just for now. Maybe scrambled eggs, chicken broth etc.  Mashed potato, pieces of de-boned fish....
Try to tempt her appetite if you can.
The vet might also be able to prescribe an appetite stimulant. But an anti-nausea drug should help.