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What causes my ferrets spleen to enlarge?

My ferret was sleeping a lot and not playing. His nose went white and we noticed he had an enlarged organ. The vet put him on antibiotics for 10 days. He was still going to the bathroom, eating and drinking although not nearly as much so I had to give him water with a syringe. After the 10 days the swelling went down and he was starting to walk around. The vet gave more antibiotics. That night he wasn't acting any different. I gave him his pill and he had a seizure. He never had one before. He passed away. I want to know what might have happened to my boy :(
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