The scenario you describe waking up with an eye uncomfortable is often due to : 1. sleeping under a fan or with air moving in the bedroom. If that is you turn it off. 2. People that sleep with CPAP for sleep apnea. If that is you use a lubricating gel at bedtime every night 3. People that have scratched their cornea and it has not healed properly (recurrent corneal erosion) Use lubricating gel (not regular tears) every night for minimum 4-6 months. 4, People that sleep with eye partially open (previous eyelid surgery, previous facial paralysis (stroke, bell's palsy) Rx same gel or lubricating ointment at betime.