Avatar universal

clomid and birth defects?

is it true that clomid raises your chances of having a baby with birth defects?
11 Responses
294043 tn?1354207946
Nope, it's not true.  My doc told me that chances of birth defects as well as of miscarriage are the same for clomid users as they are for everyone else.
Avatar universal
actually  there is a higher rate of birth defects with clomid but it is still very small, and not much higher than the general population.  what they don't know if whether this increase is actually due to the clomid itself or due to the infertility.  You can read about this in a myriad of medical journals on medline which is what I have done.  The increase is so slight (maybe 1% in general population compared to 3% with clomid, can't remember exactly) that I don't think it would stop many women who are having problems conceiving from trying it.  It has been used since the 1960's and if the risk was very great they would have pulled it from the shelves a long time ago!!
Avatar universal
I have a child with multiple birth defects after taking Clomid.  I do not think it was coincidental that I have also met other parents in the hospital setting that also have children with defects after taking  Clomid.  I am no scientist but I think there is a correlation.  I only wish I had known this before I took the drug.  I love my son and would not trade him for the world but drug companies can manipulate study results to look favorable for them and that is not fair to the consumer.
380530 tn?1239162538
My clinic says there is no research that supports the idea that Clomid causes birth defects.  It's out of your system before implantation.

1439597 tn?1283966253
A new study from the Centers for Disease Control and Prevention (CDC) reports that Clomid (clomiphene citrate) has been found to be associated with an increased risk for 9 different types of birth defects. On November 26, 2010, the medical journal, “Human Reproduction,” published online the results of the study on the popular fertility drug. The implicated abnormalities included anencephaly (open cranium with absence of a brain), esophageal atresia (closed esophagus), omphalocele (protrusion of part of the intestine through the abdominal wall), craniosynostosis (premature fusion of the skull bones), 3 different types of heart defects and a defect of the brain (Dandy Walker malformation). The ninth defect (cloacal exstrophy) involves multiple defects of the gastrointestinal and genitourinary tracts.

After taking into account such factors as maternal age, history of prior miscarriages, smoking, use of alcohol and obesity, the epidemiologists found increased risks ranging from 60% for septal heart defects to 440% for cloacal exstrophy. Drawing on 8 years of data from the National Birth Defects Prevention Study, Dr. Jennita Reefhuis and her colleagues compared the drug’s exposure to 36 types of birth defects with those of 6,500 live born babies born without major birth anomalies, used as controls. No less than 22 of the remaining 27 birth defect categories likewise showed an increased risk, ranging from 10% up to 170% after exposure to Clomid, although the numbers were insufficient to reach the scientific standard for "statistical significance."

The preliminary results of this study were first reported by CDC at the annual convention of the Teratology Society on July 2, 2008. This study thus should not come as a surprise to the FDA, which has been sitting this and other published studies for years. Having researched the subject for decades, I can assure that there are numerous studies reporting an increased risk of birth defects following the use of clomiphene. The drug also has a long half-life and studies have shown it to remain in the system for up to 54 days after ingestion. Perhaps now the FDA will finally take some action to require a warning on the drug's labeling.

Avatar universal
  Chlomid does cause birth defect, I took 100mg  and got pregnant on the second cycle.  At my 12 month  appointment , we found out that  our baby had a radial club hand( missing  a bone in the forearm). After going from doctors to doctors , performing testing as  she could very well had  VACTERL association due to her limb problem , 6 weeks later we were forced to terminate the pregnancy(at 18 weeks) . There were too many risk of other unknown problems till the child was born

Avatar universal
I also took clomid - a double dose as I recall -  My child was born in 1978 with VACTREL Syndrome.  I went through full genetic testing, but there was nothing found.  I highly suspect CLOMID.  I also thought it was Bendectin a morning sickness drug, but that was later ruled out - however I am still suspicious.  Thanks for sharing your information as that same daughter is 1 1/2 month pregnant.  She had several of the anomalies including radial club hands.
Thank you for your bravery in posting this. I took soy isoflavones in a relatively high/medium dose because it was recommended as a natural alternative to Clomid, having a similar impact on the hormones of the body (estrogen booster I believe). At the time the research said Clomid and soy were both safe. Part of the logic was that you stopped taking them long before the baby was even conceived, so how could it affect the baby? I stopped taking it weeks before conception. Out of my 4 children, that baby was the only one I took anything with and he was also born with VACTERL syndrome. It should be noted that the VACTERL comes from something going wrong around six weeks after conception, so that is a very long time afterwards. All of my other children are perfectly normal and healthy.  One third of children with VACTERL are born to diabetic mothers (I am not diabetic), and no one knows why. I suspect it is because of the association between diabetes, obesity, and elevated estrogen. I know one other woman who also did soy isoflavones and whose son had similar birth defects. We were both on doses that are a little higher than what someone would typically take. We could just be the anecdotes-coincidences. There are no genetic causes of the syndrome in my child's case. Obviously, more studies need to be done, but I feel terribly guilty about it even to this day. If I had to do it over again I would have tried longer without it. That said, if I had exhausted all other options and that had been my only chance at conceiving, I would've taken the risk, I just wish I had known, that I would've tried a lower dosage.
2116985 tn?1334628542
I took clomid 5-9 50mg first time & my baby is nearly 6months, he is fine, I think it depends on a lot of things but especially how high dose & how many times the drug was taken.
You shouldn't continue the next dose until you have seen your AF.
Avatar universal
My dd is fine also all drugs have risk.
Avatar universal
I just termated my pregnancy three weeks ago at 22 weeks. I also used clomid they found that my baby had severe clug feet, sever spinabifa, brain defects and possibly more. I have a five year old that is health. I blame the clomid. Wish I had researched it before I used it. We are going through such a heartbreaking thing and will never be the same.
Avatar universal
I took 100 mg dose for 5 days in order to have my son.  The fertility clinic said there no added risk in birth defects.  It's the same as any pregnancy.  I have a beautiful two year old because of Clomed.  Talk to a specialist to get the most up to date information.  Good Luck and baby dust to you!
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