It can take a few weeks for the meds to take effect that u notice....u also should be modifying ur diet and lifestyle to aid the meds in helping calm this down.That said not everyone does well on a PPI and do have to try the H2 inhibitors....like pepcid....but try to give the other meds more time and do follow tips for modifying diet and lifestyle.
Elevate the head of ur bed which will help keep the acids down where they belong....and do not eat 3 to 4 hrs b4 laying down....it is very important that u follow these suggestions as they can help.
Same with avoiding the foods and bevs that can trigger a flare up....meds can not help if u continue to eat and drink things that cause more acids to be produced.
Drs also suggest eating 4 to 6 small meals a day instead of 3 larger ones, this will help in using up the excess acids being produced.
Look at the info on foods to avoid in the Health Pages for other tips and lifetsyle changes that can also help.
http://www.medhelp.org/health_pages/list?cid=236