High Amylase and Lipase (5x's) No Diagnosis

[BarbaraLDantone]

I also need a “red herring” explanation please. With Amylase and Lipase both over 5 times normal, gas, continual deep pain in upper right quadrant, fatigue and nausea, I'm at square one in getting any answers. Tests since Dec 2015: CT, Colonoscopy, Endoscopy, MRCP, Celiac blood test - all "appear normal". Primary Care Doc says "Nothing more to do. Everything looks fine". But when the Gastroenterologist gave me the "fish theory" it sounded like he thinks it's all a figment of my imagination. I don't smoke or drink and control diabetes with diet, exercise and minimum dose of Metformin ER. Fats are very problematic. I need some hope and direction! Any comments appreciated. It is good to hear I am not alone although I do not wish this on anyone. Does anyone have any suggestions or comments?

[TheLightSeeker]

It sounds like a typical case of cholecystitis, however pancreatitis has to be ruled out as well.
These are  2 conditions where both  Amylase and Lipase levels are elevated, however, cholecystitis affects the  upper right quadrant.
The lack of a diagnosis, should this suspicion prove to be correct, puzzles me, as it is rather common and simple to diagnose. I guess, there's always the possibility of missing what seems to be the obvious to most doctors.
If your gastroenterologist is not willing to be supportive and work with you, perhaps, seeking a 2nd opinion would be the logical next step. Ask for a HIDA scan which has high sensitivity, if the ultrasound does not help in establishing a diagnosis.
BTW, diabetes is a  risk factor in both cholecystitis and pancreatitis.
Best wishes,
Niko