Upper Endoscopy Results

[LO55115]

I had an upper endoscopy and received the following results:

PART 1:  DUODENUM, BIOPSY
     DUODENAL MUCOSA WITH PRESERVED VILLOUS ARCHITECTURE AND NO SPECIFIC
ABNORMALITY.

PART 2:  STOMACH, FUNDUS, BIOPSY
A.          OXYNTIC MUCOSA WITH FOCAL LYMPHOID AGGREGATES.
B.     NO H. PYLORI IDENTIFIED.

PART 3:  STOMACH, ANTRUM, BIOPSY
A.          GASTRIC MUCOSA WITH FOCAL LYMPHOID AGGREGATES.
B.     NO H. PYLORI IDENTIFIED.

Could someone please explain what this means in layman's terms? Especially the "oxyntic mucosa with focal lymphoid aggregates" and "gastric mucosa with focal lymphoid aggregates." Thanks.

[CalGal]

Part 1 - the surface membranes in the duodenum appear normal. There are myriad of 'finger-like' projections (villi) in that tissue and when they are blunted/shortened it can suggest the presence of issues such as celiac disease.

Parts 2 - the area the biopsy was taken from - the fundus, the top portion of the stomach - showed the presence of 'glandular cells' = oxyntic. Glandular cells are typically specialized to secrete substances such as acid component. Doesn't seem to be anything there to be concerned about. Focal = localized, discrete. Lymphoid aggregates = groups of white blood cells designed to fight whatever is perturbing the area. May or may not suggest you could be fighting 'something.' However, the presence of H. pylori has been ruled out in the biopsies.

Part 3 - lower down in the stomach = antrum. Same situation as part 2.

These findings - which don't seem too perturbing - would have to be correlated with all other tests you've have to help your doc reach a diagnosis/conclusion.

[EggPlant23]

Increased lympocytes means a Marsh 1 sign in coeliac biopsies. It's non specific but with other supportive diagnostics could still be coeliac. The term lymphoid aggregates could be gastritis - inflammation of the stomach - which is also a possibility of coeliac. Here is some reliable information:
Lymphoid follicles /aggregates in gastric biopsies have been traditionally linked to Helicobacter pylori gastritis, and less commonly to other inflammatory and neoplastic conditions. The frequency of such aggregates in normal stomachs has yet to be adequately evaluated.