What may cause vomiting after drinking fluids hours after a tiny bit of alcohol?

[Pratum]

I'm at a loss on this one, and my gastroenterologist is as well. Really hoping someone can give me some guidance. I'm having an issue where even a tiny bit of alcohol (e.g. 3oz of wine, or less than 1oz of spirits) triggers something in my body that hours later causes me to not be able to drink fluids without vomiting them up.

Let me be clear that this is not the normal kind of nausea brought on by overdrinking. It's at the point where I can have had a single very small drink with dinner and then run into this issue seven or more hours later. I also recognize that "don't drink any alcohol ever again" is the easy answer, but I would really like to understand what's going on and what might be behind my symptoms since they've been getting much worse over time. Occasionally I will get queasy if I've had water to drink at night but no alcohol whatsoever in months, and I'm a bit concerned that could be the same issue progressing.

If I consume alcohol (even tiny quantities) and then I don't put any fluids at all in my stomach for the remainder of the evening, I don't have any vomiting issues. Drinking fluids right away seems okay, though can make me a little queasy. But many hours later if I have a glass of water or something similar, I will vomit. This happens every time, including 7 or more hours after the alcoholic beverage. After vomiting, the nausea feeling goes away right away. However, even a single sip of water after to try to rinse the acid out of my throat, and I will go abruptly from feeling perfectly fine again to vomiting a second time. Even a tiny amount of fluids in my stomach during that period of time and it will protest by vomiting. Eating doesn't seem to have the same effect for some reason, though since it's gotten really bad I haven't wanted to test that out by trying.

Acid-blocking medication helped, but it seems to have been getting progressively worse, just masked by the medication. I tried Pepcid AC on a whim since it seems to help some people with Asian flush (I'm not Asian and my problem isn't flushing, but I was willing to try anything at that point). Pepcid AC used to be able to prevent it but then wasn't enough. I then was prescribed Tecta, which when combined with the Pepcid eliminated the problem entirely for a while. But now that's not enough to stop it from happening either. I have also tried Dicatel and twice a day Tecta, but without noticeable improvement. I've tried avoiding alcohol entirely for months, having only two drinks a year, etc. but unfortunately that doesn't seem to have improved things at all.

I have had an endoscopy of my upper digestive tract (though obviously not when I had been drinking recently), and the results appeared normal.

I realize you probably can't give me a definite answer on this, but I would really appreciate any possible theories or lines of investigation to pursue. What could possibly be going on that would be triggered by a tiny amount of alcohol and cause my stomach to protest so violently if I have any fluids numerous hours later?

[specialmom]

There is something called alcohol intolerance.  It's a real thing.  https://www.mayoclinic.org/diseases-conditions/alcohol-intolerance/symptoms-causes/syc-20369211  Are you drinking the same things you always have? Like everything else, there may be ingredients in it that you are reacting to explain why you all of a sudden have this.  Sulfites are a big one that can cause intolerance.  Grains are in alcoholic beverages too that some people react to.  And histamine can come from fermentation.Do you get anything else like skin flushing or a runny nose?  

Some people have an irritated stomach lining and the alcohol can create an issue there as well.  

I'd run it by your doctor especially since it is so extreme.