I have a double MTHFR gene mutation also. Basically you cannot absorb the Folic acid unless your taking metholated folate. There is a website called MTHFR .com that will explain all you ever wanted to know about the gene mutations and explain about folate. Typically B12 and B6 are recommended supplements for people with this gene mutation. It can also be a cause for pregnancy loss. I have lost several pregnancies and once I got my thyroid regulated and on the metholated folate I've been successful carrying this pregnancy so far. I'm 13.4 weeks today. I hope this info helps. Your doctor will have to determine if clomid is the right med for you. There are also meds like Femara that may work better for you.