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Langerhans cells??
I have read that Langerhans cells are present on the fore skin of uncircumcised male. R these cells on the outer part of the fore skin or its on the inner part of foreskin. If a uncircumcised male pull backs his skin then an inner part of foreskin is visible. Where exactly theses cells r located
Just went through your past posts and I have to ask you to drop this line of questions because you are going to be reported. You had a no risk situation and you are trying to find some why to make it risky.
are dendritic cells[2] in the epidermis,[3] containing large granules called Birbeck granules. They are normally present in lymph nodes and other organs, including the stratum spinosum layer of the epidermis. They can be found elsewhere, particularly in association with the condition histiocytosis.
On infection of an area of skin, the local Langerhans cells will take up and process microbial antigens to become fully-functional antigen-presenting cells.
Generally, dendritic cells in tissue are active in the capture, uptake and processing of antigens. Once dendritic cells arrive in secondary lymphoid tissue, however, they lose these properties while gaining the capacity to interact with naive T-cells.
In the rare disease Langerhans cell histiocytosis (LCH), an excess of these cells is produced, which can cause damage to skin, bone and other organs.
Evidence indicates that Langerhans cells act as initial cellular targets in the sexual transmission of HIV,[10] and may be a target, reservoir, and vector of dissemination.[11]
Langerhans cells have been observed in foreskin, vaginal, and oral mucosa of humans; the lower concentrations in oral mucosa suggest that it is not a likely source of HIV infection relative to foreskin and vaginal mucosa.[12]
On infection of an area of skin, the local Langerhans cells will take up and process microbial antigens to become fully-functional antigen-presenting cells.
Generally, dendritic cells in tissue are active in the capture, uptake and processing of antigens. Once dendritic cells arrive in secondary lymphoid tissue, however, they lose these properties while gaining the capacity to interact with naive T-cells.
In the rare disease Langerhans cell histiocytosis (LCH), an excess of these cells is produced, which can cause damage to skin, bone and other organs.
Evidence indicates that Langerhans cells act as initial cellular targets in the sexual transmission of HIV,[10] and may be a target, reservoir, and vector of dissemination.[11]
Langerhans cells have been observed in foreskin, vaginal, and oral mucosa of humans; the lower concentrations in oral mucosa suggest that it is not a likely source of HIV infection relative to foreskin and vaginal mucosa.[12]
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