After 16 week with Interferron + Simvastatin

[Otan]

Took 1st dose on 21 Oct 2011 and on 11 Jan 2012 HBV DNA not detected.  
Below is the lab history,                          

Date            13/9  20/10  21/10  11/11  16/11  9/12  15/12  6/1/12  11//1/12
                                   1st dose                                   12th dose
SGOT                    35*                          49*             63*                  67*
SGPT                    63*                          78*             89*                  90*
HBsAg     366.44  255.68                                                              176.4*
HBV DNA2.54x10^5                                                                   no detect

Result on week# 16

SGOT  86
SGPT  130
HBsAg  10.49

When HBsAg became zero, then what to do? Is that time to stimulate Anti-HBs?

[Otan]

Hi... Sorry left this conversation too long.
Just did my blood check 21-Feb-2020 found my HbsAb is 165 mlU/mL

[halt651]

Hi, glad to hear that you are doing ok!
let me ask some questions (because I could not find in thread) what made you eligible with Peg-inf  treatment at the beginning? was it self administrated?
even though you have hbsab+ does your doctor check your liver with ultrasound?  and does your dr check if you still have cccdna ?  

[faithhopegod]

great info

[MyLife16]

Hi how much is ingerferon? Have you tried using it?

[stef2011]

i believe he/she stopped entecavir long time by now, i am not sure but i remember she reported using hbv vaccine to boost hbsab and stopping entecavir...but not sure, have not time to check all threads and just using my foggy memory

[andrey19]

Are you taking nucs after hbsag loss as per Studyforhope and Steff suggestions?

[stef2011]

very happy to know both your working life and your health have had such improvement.

[Otan]

Good news...
I checked my HbsAb on 14 Apr 2014 was 112 miU/mL. Increase from before that stable around 20.

And this result I got from my Medical Clearance for my new job in Iraq to the same company I lost my job before in Saudi because of Heps B.
Thanks God...Hope more HBVers get cured.

[Roshni9038]

Congrets oten

[Otan]

Thanks Steff for confirmation HBV IS over.
Iam a father of  a14 year old boy.

I try that to avoid the oily food.

[stef2011]

very good hbsab looks like stable around 20 now, hbv is over for sure

to be superhealthy i think you just have to work on fatty liver since normal alt for women is less than 19

[Otan]

My last update,

24/5/13  SGOT-27  SGPT-35; HBsAg- Non React; HBsAb- 15.34
12/8/13  SGOT---  SGPT---   ; HBsAg- Non React; HBsAb- 23.32

My recent update
6/11/13 HBsAg- negative; HBsAb- 21.46
8/11/13 Vaccine with Euvax B (20 Ug/lm)
29/1/14 HBsAg- Negative; HBsAb- 26.30

[stef2011]

http://www.vitamindwiki.com/Low+cost+vitamin+D+Blood+Tests

http://www.vitamindwiki.com/Quick,+free,+self+test+of+vitamin+D+deficiency

http://www.vitamindwiki.com/Instant+vitamin+D+test+now+available+for+doctors+to+test+at+very+low+cost+%E2%80%93+March+2013

what bastards, 200usd is impossible....check the links for the only extremely cheap vitamin d tests, it worths check even if you are under the sun for so ling time, if there is a phatogen or a bad vdr receptor vitamin d could be low even in your situation

[Otan]

Steff,
I think I expose to sun a lot.
I live in thropic city Jakarta, secondly I dont work in office but field. Often I work under the sun from 7 - 12 and 13 - 17 daily.

Once I asked for vitd25oh check as you suggested but, it cost like around 200 usd. So Did not check.

[stef2011]

i dont think the issue is hbv but you know nobody can tell for sure...i d work on vit d first, if you are not exposed to sun all day and equatorial country your levels should be low and you can start increasing them by long hours sun exposure or supplements with combined vit k2.
dose must be at least 5000iu daily and vit k2 100 or 400mcg daily.high dose k2 can also be found on fermented vegetables or some european cheese

i d check vitd25oh levels only after 5-6 months supplements, it is strange the test is expensive here in europe cost is from 16 to 30€

before taking the vaccine it is best to increase d levels to 80-90ng/ml and then see hbsab levels and ast-alt.i dont know if you seen latest study:
vitamin d correlates to hbvdna and highest d levels are found in low/und hbvdna

normal vit d levels are found on hbv carriers clearing hbsag off therapy

[Otan]

Steff,
Yes, I did ultrasound at Gleaneagles- Penang Malaysia on 3rd Apr 2012 and were AST-93  ALT-153, HBV DNA-und, HBSAg-6.9 index (reactive), HBSAb-1.3 mIU/ml
Ultrasound result;
The liver is normal in size and diffusely increases in echogenicity. No focal liver lesion. No dilated intrahepatic duct/CBD.
The gallbladder appear normal. No gallstone.
The head of pancreas, spleen, and both kidney are normal. RK=10.9 cm; LK=11.1cm in bipolar length. No hydronephrosis. No renal calculi. No ascites. Normal abdominal aorta.

Impression:
Fatty Liver

For vitd25oh, I did not check. I checked the cost was expensive

For HBSAG type, I dont  know what my type is
I may try other type of vaccine.

[stef2011]

did you check ultrasound so that we know the abnormal ast-alt is due to fatty liver and not remaining cccdna in the liver?

do you also have your vitamind25oh to optimum levels?vitd25oh>50ng/ml should help control and resolve fatty liver is present

there is also an hbv vaccine produced in israel since few years, it has all hbsag types (and much more potent than normal hbv vaccine which has only one type of hbsag).we open a thread about it, this is also distributed in some asian countries i believe

[Otan]

Cyrus,
Sorry Cyrus to reply you late, I was at Rig with less facility recently.

My last update,

6/3/13 SGOT-26  SGPT-37; HBV DNA-undtc; HBsAg Qty- <0.05 iu/mL; HBsAb- 26.12; HBeAg- Non React; Anti HBe- React

22/4/13 SGOT-27  SGPT-46; HBsAg- Non React; HBsAb- 20.4

My recent update,

24/5/13  SGOT-27  SGPT-35; HBsAg- Non React; HBsAb- 15.34
12/8/13  SGOT---  SGPT---   ; HBsAg- Non React; HBsAb- 23.32

With me, I feel fit, normal except my finger joint.
I do my work fisically with my hand, lifting load.
Before interferron, if I worked over with my hand (finger) I felt cramp and will recover after a week rest.
But now, the cramp gone after the rest but left the finger joint like stiff.
But it does not effect my work too much.

I am welcome for any questions regarding my theraphy.
Sorry again for reply late.

[cyrus131]

Dear Otan,

How are you recently?  Grateful if you could kindly share your updated status.  Thanks.

Regards,

Cyrus

[studyforhope]

Here are the countries where zadaxin is approved.


Argentina, Azerbaijan, Bahrain, Brunei, Cambodia, China, Dominican Republic, Hong Kong, India, Indonesia, Kuwait, Kazakhstan, Kyrgyzstan, Laos, Malaysia, Maldives, Malta, Mexico, Moldova, Pakistan, Peru, Philippines, Russia, Singapore, Sri Lanka, Thailand, Ukraine, United Arab Emirates, Uzbekistan, Venezuela, Vietnam
Chronic Hepatitis B
Marketing Approval

[Otan]

Studyforhope, Steff, Cyrus

From 3rd March to 3rd Apr I took Baraclude. Now I have my Viread 4x30 tablets, but not started yet.
Will it good to take Viread while I am in HBV Vaccinasion? Does Viread kill the HBV Vaccin?

FYI, I still cannot find the Zadaxin in Jakarta (indonesia) and Nairobi ( which recenly I visited).

below is my status upodate...



6/7/12 38 dose interferron
12/7/12 SGOT-93 SGPT-142; HBSAG- <0.05 iu/ml; HBSAB-negtv
17/7/12 Start taking Baraclude 0.5mg, 1 tablet per day
20/7/12 40th dose intrfn
25/7/12  GOT-108 SGPT-171
15/8/12  Last Baraclude taken
15/8/12  SGOT 117 SGPT 207; HbsAg- not reactive
24/8/12  HBSAB- 70 mIU/mL
14/9/12  48th dose intrfrn
19/9/12  SGOT-102 SGPT-162; HBV DNA- undetct; HBSAG quanty-
<0.05iu/ml; HBSAB- 122.58mIU/mL
16/10/12  SGOT-88 SGPT-165; HBSAB- 107.13 mIU/mL

6/12/12 SGOT- 34 SGPT-53; HBSAg- non reactive; HBsAb-71.43
10/12/12 Took 1st dose vaccine of Engerix TM-B Adulta dose, r-DNA 1ml HBsAg 20 ug

8/1/13 SGOT-27 SGPT-45; HBSAg-non reactive; HBSAb-52.88
10/1/13 Took 2nd dose of vaccine
22/1/13 HBSAb-43.2
18/2/13 SGOT-25 SGPT-40; HBSAg-non reactive; HBSAb-15.1
----------------------

6/3/13 SGOT-26  SGPT-37; HBV DNA-undtc; HBsAg Qty- <0.05 iu/mL; HBsAb- 26.12; HBeAg- Non React; Anti HBe- React

22/4/13 SGOT-27  SGPT-46; HBsAg- Non React; HBsAb- 20.4

[cyrus131]

Dear Otan,

How are you recently?  Kindly if you could share your updated status, please.  Many thanks.

Regards,

Cyrus

[Otan]

Stef n Studyfh,
Thanks a lot...

[studyforhope]

The fact that no vaccine was used in the replicor zadaxin enhanced patients, can be interpreted such that the adjuvant is the critical component, in this case zadaxin, since small amounts of surface antigen is still present in these patients anyway.
This is not to say that a vaccine would not have driven the resulting titer even higher. But it is also possible that he alum contained in these recombinant vaccines would have had a negative effect on the overall outcome.
We must not forget that while the AB titer can be easily measured, the critical effect operating here , invisible to us, might be a reinduction of the all important TCell response. As a matter of fact, we can be quite sure that the boosting in AB titers that was achieved resulted from a T helper response that stimulated the B cells to produce more antibody.
As such we might see the antibody response as a cheap surrogate marker of a more global TCell response that will include the precious cd8+ cells, that have the capacity to clean and clear more remaining infected cells.

[studyforhope]

Alum is still a necessary ingredient of the prophylactic HBV vaccine. But it promotes what is called a type II TH2) response, where a cytokines mix is induced that does not propel a cytotoxic TCell response. But rather suppresses it. It is more useful for an organism, that is not yet infected with an intracellular parasite, to limit its reaction to the production of infection preventing antibodies. This also effects the subtype of the antibody within the IGg class that will be produced, from strictly neutralizing to cytotoxic.
If you search joerg reimann and reinhold schirmbeck in pubmed you will find wonderful papers on HBV response induction with various of surface plus core plus RNA and adjuvant approaches and the tremendous variation in response they achieved. All in mice, but no one else has done that kind of highest quality analysis on how a therapeutic vaccine could be composed.

At very low levels of surface antigen, AB tend to become visible even in the presence of the unbound antigen. In this case however, just as in the replicor patients without immunoenhancing therapy, the low visible titer is indeed a low titer.
This phenomenon also shows that the kinetic of immuncomplexing by the ABs is somewhat slow, therefore we have free components present.
This is of great significance, since it points to the need of a very high antibody level if the goal is prevention of local intrahepatic reinfection as it exists after seroconversion or after liver transplant.