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Best Treatment for HBv

I am 53 years old last month I have went for preventive health check up and based on the report findings the followings noted; SGOT 83 IU/L ,SGPT 200 IU/L , Doctor recmended me to see the Gastro.consultant , the gastro.consultant advised me to go for others test the result are as follows: Anti-dsDNA 16.6 IU/ml. , HBsAg test value 9520(Reactive) ,HCV,IgG test value 0.12 ( non Reactive) ,Anti Nuclear Antibody ( ANA) 0.12 , Immunoglobulin IgA 279 mg/dl , Tissue Transglutaminase antibody IgA 0.40 U/mL , Anti Mitochondrial Antibody , Serum 0.26 UL/ml , ASMA 2.70 U/mL , LKM Antibody 0.02 U/ml , Hepatitis B envelope Antibody test value (Ab) 43.0 ( Reactive) , Hapatitis Be Antigen ( HBeAg) 0.15 ( Non reactive),AFP 4.38ng/ml  , HBV DNA Quantitative,Real Time PCR 5156250 IU/ml. Based on this the Doctor advised me for the treatment  Tab.Entavir 0.5 mg one daily. Here i went for second opinion with Lever specialist consultant and he advised me to go for Fibroscan which the result is 5.91 Kpa ( Negative for fibrosis).Now the lever specialist advised for Viraferon Peg 80 mg once in a week and monitor CBC & S creatin every 15 days.I have not started the treatment yet as I am going out of India for 1.5 months as Doctor told me that this treatment will be given under there supervision , please suggest which treatment is suitable under these report.Also with vaccine this problem will be solved and how long i have to take this treatment.
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Avatar universal
only if hbsag goes less than 1500iu/ml peginterferon add on before 3 years of antiviral makes sense
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Avatar universal
Sorry some correction in 24 hours urine test , the values is 375 not 300mg.
Looking forward your revert.

Thank you,
Helpful - 0
Avatar universal
Hi stef

Thanks for your revert ,
Please find the Ca. result:
Calcium, Serum:

- on 23 Feb.2015: 10.60 mg/dL ( Ref.range 8.8 - 10.60)
-on 7 March 2015: 10.50 mg/dL .
-on 3 April 2015: 10.50 mg/dL.
- on 1 may 2015: 11.20 mg/dL.    
-On 10 may 2015: 9.6mg/dl.      
-On 13/6/2015 : 9.8 mg/dl.

24 hours urine test result:
- 13/6/2015 : 300mg

Doctor advised me to redo the test on 1st week of august as he had given me medicine tablet 1 daily , so once this 1 month over then test to be repeated for both 24 hours urine and serum calcium.

No they have not told me any thing on sarcoidosis, I will check with him on my next visit.

How you rated my progress on my latest result on HBV.on my previous mail.

Looking forward your opinion.

Thank you,
Helpful - 0
Avatar universal
telbivudine alone is not ok, it is too weak and high resistance.making a combo of tdf plus telbivudine has shown a repair effect on kidneys so no need to take telbivudine monotherapy

as to calcium what are blood test results on calcium and urine tests?

creatinine 1.09 is usaully not high, most tests are normal till 1.3

it is good to stay off vit d and take a drug to lower calcium.did they confirm you have sarcoidosis?
Helpful - 0
Avatar universal
Hi Stef
Hope you are doing good ,
I met with my Doctor and he suggested to change TIRAVIR 300mg with SEBIVO 600mg due to Creatinine report but asked me to do one more blood test for KFT and based on the report he will confirm for change of medicine.
The creatinine latest report is 1.09 mg/dl ( High )
Please suggest ,
The other report is as under:

HBV DNA Quantitative , Real time PCR : Plasma
- on 28 Jan.2014- 5156250 IU/mL.
- 1 May 2014:  - 33181 IU/mL.

- 9 August 2014: = 5.72x10^2 IU/ml.

- 8 Nov. 2014: 47.5 IU/ml.
- 20 Feb.2015 : 6.04 IU/mi.
- 13/6/2016: HBV DNA NOT DETECTED.

HBsAg Quantitative:

- on 28 Jan. 2014:  : 7767.68 IU/mL.

- on - 1 May 2014:  6812.40 IU/m

- 9 August 2014: 3585 IU/ml.

8-  Nov.2014: 4633 IU/ml

- 20 Feb.2015 : 5174 IU/ml.
- 13/6/2015: 5431 IU/ml

FibroScan:
On 26 Dec.2014 : 4.7.
On 9 August 2014 : 4.9.
on 13/6/2015: CAP ( dbm) Median 270 , IQR 21. , E(kpa) Median 3.5 , IQR 0.5 , IQR/med 14%.

I also met with Endocrologist related to my serum calcium & 24 hours urine ca. both are high so for he has given medicine for 1 month and thereafter the test to be repeated , till such time i am not taking vitamin D3 .
Please suggest me on this new medicine stated above and also your comments on the progress based on my report.

Thank you,



Helpful - 0
Avatar universal
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160567/

check out this article, your excess dysregulation maybe due to extremely high 1.25oh too or sarcoidosis.we can get some clues from this article too
Helpful - 0
Avatar universal
Thanks Stef , I will consult Doctor and update you .
Helpful - 0
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