Aa
Chronic Hep-B still active after 5 years
I am a patient of Chronic Hepatitis B. I have been suffering from this disease since January 2009. I am constantly following up my disease since its diagnosis. I have undergone through a pegasys injection + Hepsera Tab therapy for one year from May 2009 to April 2010. I have taken Entacavir 0.5 mg from May 2010 to October 2013. and i have been taking oral anti viral tenofo-B from November 2013 to April 2015 and in May 2015 Doctor prescribed me to start centaurus (Entecaver) in addition with Tenofo-B. My Medical history includes HBV DNA by PCR Quantitative is under 10 IU/ml after 5 Years. But HBeAg is still Reactive 27.09 and Anti-HBe is Non-Reactive 3.3. My ALT is 32. My RBC is 4.5 * 10^12/l, My Hb is 13.8, My Platelet Count is 215 * 10^9/l.
i see.. thanks.
looks like we have the same track on numbers for the AST/ ALT and HbeAg etc.. now my ALT/AST and others are normal. its my first time to test hbsag quantitative to see how tenofovir works directly with my HBV.
looks like we have the same track on numbers for the AST/ ALT and HbeAg etc.. now my ALT/AST and others are normal. its my first time to test hbsag quantitative to see how tenofovir works directly with my HBV.
Not too serious side effects. Sometimes headache but I guess its not related to meds. When i add vitd3 less side effects.
congratulations.. :)
You are very lucky.. I would like to ask if you add some herbal supplements and other meds? I was attacked by some "herbal advocate" in a forum that they were treated by herbal medicines and make hbsag negative. I dont want to waste my time there anymore and argue.
You are very lucky.. I would like to ask if you add some herbal supplements and other meds? I was attacked by some "herbal advocate" in a forum that they were treated by herbal medicines and make hbsag negative. I dont want to waste my time there anymore and argue.
I am totally cured.
See my results: http://www.medhelp.org/posts/Hepatitis-B/My-All-Test-Result-After-12-Months-Treatment-of-Entecavir-I-am-cured/show/2355051
See my story: http://www.medhelp.org/posts/Hepatitis-B/Urgent-Advise-for-Entecavir-Usage/show/2044528
See my results: http://www.medhelp.org/posts/Hepatitis-B/My-All-Test-Result-After-12-Months-Treatment-of-Entecavir-I-am-cured/show/2355051
See my story: http://www.medhelp.org/posts/Hepatitis-B/Urgent-Advise-for-Entecavir-Usage/show/2044528
Hope you clear hbsag, I'm on tdf also. But stopped due to hematuria, do you feel any side effects?
it is but it depends on the doctor. personally i want to continue and check hbsag quantitative and lets see how it works directly to HBV. Now all other tests in me is normal i will focus on hbsag quantity and if it showing decline I will continue to take my antiviral because some cleared (the lucky ones) with antiviral therapy. :) Some needs peg inteferon with very low hbsag count.
hmm somehow i would think im in immune clearance phase at the time of e-seroconversion. I am genotype A and 30yrs old. here some details:
October 2014:
HbeAG+
AntiHbe-
HBV DNA 118million
ALT=400+
AST+300+
November 2014:
HbeAG+
AntiHbe-
HBV DNA 7000+
ALT=300+
AST=200+
December 2014:
HbeAG-
AntiHbe+
HBV DNA 141
ALT=120
AST=50
June2015:
HBV DNA undetected
ALT=44
AST=36
So I am not sure if its just coincidence that when I starting taking Viread helps the e-seroconversion but looks like it help ti improved all numbers.
Now i am waiting for my hbsag quantitative and see how it works directly to HBV.
October 2014:
HbeAG+
AntiHbe-
HBV DNA 118million
ALT=400+
AST+300+
November 2014:
HbeAG+
AntiHbe-
HBV DNA 7000+
ALT=300+
AST=200+
December 2014:
HbeAG-
AntiHbe+
HBV DNA 141
ALT=120
AST=50
June2015:
HBV DNA undetected
ALT=44
AST=36
So I am not sure if its just coincidence that when I starting taking Viread helps the e-seroconversion but looks like it help ti improved all numbers.
Now i am waiting for my hbsag quantitative and see how it works directly to HBV.
Most patients e-seroconvert before the age of 40, genotype C generally takes longer time. NA antivirals only inhibit replication of HBV, that is indicated by low or undetectable serum hbvdna, leading to reduction of inflammation, hence normal ALT and little damage to the liver.
Natural e-serconversion occurs during Immune Clearance phase, marked by flares in ALT. If the period of Immune Clearance is long, that is, frequent flares of ALT without e-seroconversion, liver will be damaged as indicated by fibrosis. So whether to treat or wait during Immune Clearance phase is often a difficult decision to make. These days, doctors can be guided by Fibroscan - if serious fibrosis is detected, then treat.
Natural e-serconversion occurs during Immune Clearance phase, marked by flares in ALT. If the period of Immune Clearance is long, that is, frequent flares of ALT without e-seroconversion, liver will be damaged as indicated by fibrosis. So whether to treat or wait during Immune Clearance phase is often a difficult decision to make. These days, doctors can be guided by Fibroscan - if serious fibrosis is detected, then treat.
And by the way I never take interferon treatment., So what makes my e-seroconversion in less than 3months? I only take viread that time and i test this HbeAG and anti Hbe every month. Also i developed anti Hbe.
hi i e-seroconverted to during my treatment in less than 3months by Viread. I am e-positive since 2009 and from there i only take lamivudine for 3months and stop and ignore. I just resumed to have attention on my HBV last October 2014 and im still e-positive. Meaning I am e-positive for almost 5years wthout seroconverting naturally. And after taking viread become e-seroconverted, now im not sure if its taking Viread or immune system that makes the seronconversion to e.
Thank you for asking me. I am not a doctor.
All your numbers look good to me. You started treatment when you were HbeAg positive, so you were in the Immune Tolerance or Immune Clearance phase.
To me, your doctor seems to be concerned that you are still HBeAg positive and that is why he is now adding Entecavir. It is always my opinion that you cannot make HBeAg negative by treatment, some patients do change from HBeAg positive to HBeAg negative during treatment, especially when treated with Interferon. However, it is not necessary that treatment caused the e-seroconversion, it could be due to the patients' own immune system. A lot of patients e-seroconvert naturally. The researchers are not clear why e-seroconversion occur.
My opinion is that you should just continue with Tenofovir along, there is no benefit in adding Entecavir. Follow stef2011's suggestion, it may help.
The main thing is that you have responded to treatments, whether you remain HBeAg positive is of no importance. Your liver should be in a good state with low hbvdna and low HBsAg. Who knows, you may e-serocovert and clear your HBsAg in the near future.
Just my opinion.
All your numbers look good to me. You started treatment when you were HbeAg positive, so you were in the Immune Tolerance or Immune Clearance phase.
To me, your doctor seems to be concerned that you are still HBeAg positive and that is why he is now adding Entecavir. It is always my opinion that you cannot make HBeAg negative by treatment, some patients do change from HBeAg positive to HBeAg negative during treatment, especially when treated with Interferon. However, it is not necessary that treatment caused the e-seroconversion, it could be due to the patients' own immune system. A lot of patients e-seroconvert naturally. The researchers are not clear why e-seroconversion occur.
My opinion is that you should just continue with Tenofovir along, there is no benefit in adding Entecavir. Follow stef2011's suggestion, it may help.
The main thing is that you have responded to treatments, whether you remain HBeAg positive is of no importance. Your liver should be in a good state with low hbvdna and low HBsAg. Who knows, you may e-serocovert and clear your HBsAg in the near future.
Just my opinion.
now start vit d3 10.000iu daily and test after 4 weeks on it vitd25oh, intact pth and hbsag quant and let us know
vit d3 boost immune system and it is possible it fasten hbsag clearance, we will think about pegintf add on in the future after vit d is optimum levels
vit d3 boost immune system and it is possible it fasten hbsag clearance, we will think about pegintf add on in the future after vit d is optimum levels
Dear Doctor,
I am a patient of Chronic Hepatitis B. I have been suffering from this disease since January 2009. I am constantly following up my disease since its diagnosis. I want your expert opinion and your valuable guidance in my treatment.
Firstly I have undergone through a pegasys injection + Hepsera Tab therapy for one year from May 2009 to April 2010. During my Pegasys+Hepsera treatment my reports were as under
My HBV DNA PCR Quantitative Results were:
March 2009 - 76200000 iu/ml
August 2009 - 1790000000 iu/ml
October 2009 - 1270000 iu/ml
January 2010 - 334000 iu/ml
April 2010 - 179000 iu/ml
My HBeAg Results were:
March 2009 - 511.68
August 2009 - 309.73
October 2009 - 608.9
January 2010 - 528.6
April 2010 - 412
My Anti-HBe Results were:
March 2009 - 16.21
August 2009 - 19.42
October 2009 - 15.48
January 2010 - 27.82
April 2010 - 20.03
Pegasys Treatment of 48 weeks ended in April 2010. My Doctor prescribed me to start Entecavir 0.5mg daily after the end of Pegasys and Hepsera treatment after examining lab reports.
My Entecavir 0.5mg treatment was started in May 2010. The results during this treatment were as under
August 2010 - 56500 iu/ml
November 2010 - 72800 iu/ml
February 2011 - 66000 iu/ml
September 2011- 18600 iu/ml
April 2012 - 1059 iu/ml
October 2012 - 739 iu/ml
October 2013 - 166 iu/ml
During my Entecavir treatment. My HBeAg Results were:
August 2010 - 457
November 2010 - 508
February 2011 - 558.6
September 2011- 202.3
April 2012 - 152.3
October 2012 - 74.45
October 2013 - 65.06
During my Entecavir treatment. My Anti-HBe Results were:
August 2010 - 18.68
November 2010 - 24.69
February 2011 - 37.39
September 2011- 11.68
April 2012 - 6.57
October 2012 - 4.46
October 2013 - 4.68
During my Entecavir treatment. My HBsAg Quantity results were as follows
December 2010 - 64392.42 iu/ml
September 2011 - 29900.35 iu/ml
April - 2012 - 13230.34 iu/ml
October - 2012 - 7408.06 iu/ml
April 2013 - 49.33 iu/ml
After that i did not carry any HBsAg quantitative tests
My Entecavir Treatment of 3.5 years ended in October 2013.
Then my doctor prescribed me to start Tenofo-B 300mg daily after examining lab reports.
My Tenofo B 300 mg treatment was started in November 2013. The results during this treatment are as under
During my Tenofo B treatment. My HBV DNA PCR Quantitative Results were:
May 2014 - 34 iu/ml
October 2014 - 10 iu/ml
May 2015 - 10 iu/ml
During my Tenofo B treatment. My HBeAg Results were:
May 2014 - 61.25
October 2014 - 41.8
May 2015 - 27.09
During my Tenofo B treatment. My Anti-HBe Results were:
May 2014 - 5.39
October 2014 - 3.99
May 2015 - 3.3
I am still under Tenofo B treatment but my doctor added up Entecavir 0.5mg once again in my recent visit. He asked me to follow up after three months.
This is my complete history, Hope you could understand and help out with your valuable opinion.
I am a patient of Chronic Hepatitis B. I have been suffering from this disease since January 2009. I am constantly following up my disease since its diagnosis. I want your expert opinion and your valuable guidance in my treatment.
Firstly I have undergone through a pegasys injection + Hepsera Tab therapy for one year from May 2009 to April 2010. During my Pegasys+Hepsera treatment my reports were as under
My HBV DNA PCR Quantitative Results were:
March 2009 - 76200000 iu/ml
August 2009 - 1790000000 iu/ml
October 2009 - 1270000 iu/ml
January 2010 - 334000 iu/ml
April 2010 - 179000 iu/ml
My HBeAg Results were:
March 2009 - 511.68
August 2009 - 309.73
October 2009 - 608.9
January 2010 - 528.6
April 2010 - 412
My Anti-HBe Results were:
March 2009 - 16.21
August 2009 - 19.42
October 2009 - 15.48
January 2010 - 27.82
April 2010 - 20.03
Pegasys Treatment of 48 weeks ended in April 2010. My Doctor prescribed me to start Entecavir 0.5mg daily after the end of Pegasys and Hepsera treatment after examining lab reports.
My Entecavir 0.5mg treatment was started in May 2010. The results during this treatment were as under
August 2010 - 56500 iu/ml
November 2010 - 72800 iu/ml
February 2011 - 66000 iu/ml
September 2011- 18600 iu/ml
April 2012 - 1059 iu/ml
October 2012 - 739 iu/ml
October 2013 - 166 iu/ml
During my Entecavir treatment. My HBeAg Results were:
August 2010 - 457
November 2010 - 508
February 2011 - 558.6
September 2011- 202.3
April 2012 - 152.3
October 2012 - 74.45
October 2013 - 65.06
During my Entecavir treatment. My Anti-HBe Results were:
August 2010 - 18.68
November 2010 - 24.69
February 2011 - 37.39
September 2011- 11.68
April 2012 - 6.57
October 2012 - 4.46
October 2013 - 4.68
During my Entecavir treatment. My HBsAg Quantity results were as follows
December 2010 - 64392.42 iu/ml
September 2011 - 29900.35 iu/ml
April - 2012 - 13230.34 iu/ml
October - 2012 - 7408.06 iu/ml
April 2013 - 49.33 iu/ml
After that i did not carry any HBsAg quantitative tests
My Entecavir Treatment of 3.5 years ended in October 2013.
Then my doctor prescribed me to start Tenofo-B 300mg daily after examining lab reports.
My Tenofo B 300 mg treatment was started in November 2013. The results during this treatment are as under
During my Tenofo B treatment. My HBV DNA PCR Quantitative Results were:
May 2014 - 34 iu/ml
October 2014 - 10 iu/ml
May 2015 - 10 iu/ml
During my Tenofo B treatment. My HBeAg Results were:
May 2014 - 61.25
October 2014 - 41.8
May 2015 - 27.09
During my Tenofo B treatment. My Anti-HBe Results were:
May 2014 - 5.39
October 2014 - 3.99
May 2015 - 3.3
I am still under Tenofo B treatment but my doctor added up Entecavir 0.5mg once again in my recent visit. He asked me to follow up after three months.
This is my complete history, Hope you could understand and help out with your valuable opinion.
are you still on etv?check hbsag quant again you have high chances to clear it on etv only, if the decline stops just add pegintf to etv for 48weeks and you ll clear hbv definitively
let us know your vitd25oh and intact pth too
let us know your vitd25oh and intact pth too
I found file of my HBsAg Quantitative reports just few minutes ago. I conduct HBsAg Quantitative series of tests when i was taking entecavir 0.5mg daily treatment. Here is two and half years record of my HBsAg results from December 2010 to April 2013.
December 2010 - 64392.42 iu/ml
September 2011 - 29900.35 iu/ml
April - 2012 - 13230.34 iu/ml
October - 2012 - 7408.06 iu/ml
April 2013 - 49.33 iu/ml
After that i did not carry any HBsAg quantitative tests
December 2010 - 64392.42 iu/ml
September 2011 - 29900.35 iu/ml
April - 2012 - 13230.34 iu/ml
October - 2012 - 7408.06 iu/ml
April 2013 - 49.33 iu/ml
After that i did not carry any HBsAg quantitative tests
I just find out April 2013 HBsAg Quantitative results. I was on Entecavir 0.5mg treatment.
April 2013 - 49.33 iu/ml.
After that i did not carry any HBsAg quantitative tests
April 2013 - 49.33 iu/ml.
After that i did not carry any HBsAg quantitative tests
I found file of my HBsAg Quantitative reports just few minutes ago. I conduct HBsAg Quantitative series of tests when i was taking entecavir 0.5mg daily treatment. Here is two years record of my HBsAg results from December 2010 to October 2012.
December 2010 - 64392.42
September 2011 - 29900.35
April - 2012 - 13230.34
October - 2012 - 7408.06
Recently i did not carried out HBsAG Quantitative tests.
December 2010 - 64392.42
September 2011 - 29900.35
April - 2012 - 13230.34
October - 2012 - 7408.06
Recently i did not carried out HBsAG Quantitative tests.
Yes my HBeAg is still positive. It means viral replication is not stopped after 5 years long costly treatment. I had given my blood sample for HbeAg, Anti-HBe and HBV DNA PCR lab tests in May 2015 recently. I repeat these test after every six months.
I am surprised to know that vitamin d deficiency can play a role in working of immune system against HBV viral replication. How it is linked. However i will conduct Vitd25oh, parathormone and hbsag quantitative lab tests and report back to you in couple of days.
My ALTs and Ultrasound abdomen of Liver are normal.
My ALTs and Ultrasound abdomen of Liver are normal.
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