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HBV+Delta last result

Hello, I have HBV+Delta since 2010. Last year, I have received Peginterferon for a year from Sep 2017 to Aug 2018.Interferon induced thyroid. Now, am taking Thyroxin 25 mg. Blood test result: Lab: CRP 1, Hb 110, MCV 86.5, Leuk 4.01, B-Neutr 1.67, Trom 173, Krea 50, ASAT 115, ALAT 137, TSH 2.75, T4-V 17.4 and HDVNH 1,0 10E8 IU/ml. Please, tell me, what I do? Sorry for my english level.
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Hi is the Peg Interferon controlling you HDV?

Have you looked into any of the Clincal Trials for HDV, please get in touch with them. There are some good treatments but they are not released yet.

http://www.hepb.org/assets/Uploads/HDV-Clinical-Trial-Fact-Sheet3.pdf
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Avatar universal
Hi Imran, Before treatment viral load: HBVNh -286, HDVNh- 214, 000,000 copies. After treatment one year viral load: HDVNh- 468.000 copies. (4.68x10E5). Now, blood test: ALAT , ASAT levels, HDVNh -1,0 10 E8 IU/ml  are rising again. Now, am living in Finland. I have asked to the doctor the clinical trial for Hepatite Delta but there is no clinical trial in Finland.
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Avatar universal
Hi FINMON, so your HDV value and ALT value went down on treatment, after treatment it is going back up? What does your doctor suggest you do?
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11 Comments
peg is useless on hdv, the only cure is replicor+nuc+peg, check where trials are (not finland for sure).another option is myrcludex in combo with tdf or peg, myrcludex should be approved soon and trials should be in europe
@Stef2011. Thank you very much for your reply. I have just ordered the LivOn labs liposomal vitamin c and glutathione. I hope this Altriend's product support for my liver function until clinical trial start be in Europe. I am looking for clinical trial for HDV in Europe but no recruiting and U.S.A just started. Hope start soon in Europe. Thanks again.
add also vit d3 5000iu or 10.000iu according to your blood levels and curcumin possibly liposomal (lipolife or actinovo
I am taking SOS Health Liposomal D3 4000 IU. Is it OK? or 5000 iu?
vit d3 liposoml is a waste of money, it is easy to increase blood levels just take 1 month at 5000iu or 10.000iu of normal vit d3 in olive oil (healty origins is a cheap and good one) and then retest
Hi,
My story is well known, Hepatitis B +Delta; 1 year of PegIFN , 1 year pause; When i've stopped for 1 year  fibrosis increased from 12kpa to 18kpa,AST/ALT increased.I resumed then  PegIFN for another 2 years; after that government insurance not paiyng for treatment anymore, so I contninued on my own account but only 2 injections/month on my doctor advice; it's been 1 year since then and AST/ALT almost normal, fibrosis get down little bit from 18kpa to 12 kpa. It is financially difficult for me but i have no option, i'm basically fighting for life, waiting for new treatment options. It seems, in my case, PegINF is keeping virus damage under control but i dont know for how long; how long my body can survive on all those chemical injected.
thank you for sharing your experience vasile79. I hope you will get better and I hope soon you dont need peg anymore!  I was wondering why government insurance stopped paying for you?  
According to treatment protocol in my country Insurance granted free treatment for 2 years only; they consider that if after 2 years you are not healed then PegIFN is not efficient; in my case, it is true, i'm not healed from Delta, but keeping under control, fibrosis not advancing for 3 years already; stay on same stage.Otherwise in 4-5 years i could be gone already, who knows. I have no single symptom of disease: working abroad, practicing sport, running, etc. Only dry skin. People don't believe me that I am on edge of critical situation . I'm waiting for new treatment but who knows for how long. I hope we will get it soon.
Thanks for the message. That's really pity situation. I hope replicor will be released soon. Maybe that will help
vasile79, one more question please. did you have a basline fibroscan reading when you discover CHD ? I am wondering how long it took to get 12 kpa from f0.  
Hi halt651....I discovered HVB in 2007 ....I didn't do a Fibroscan...so I don't know how high it was on that time. My huge mistake was that I didn't took it seriously and continued with unhealthy lifestyle: food, alcohol, etc. untill 2012 when I discovered HDV. Since then healthy lifestyle.....In 2013 only I started PegIFN...and In 2015 first Fibroscan ...level maintained after 5 years....even slightly less. Need to maintain same level, somehow,  untill new treatment is released.
Avatar universal
https://ilc-congress.eu/press-release/bulevirtide-shows-promise-in-the-treatment-of-chronic-hepatitis-b-d-hbv-hdv-coinfection/

"Remarkably, 4/15 patients (27%) treated with 2mg bulevirtide + PEG-IFN-α had undetectable HBsAg levels and 3/4 patients experienced HBsAg seroconversion."

I wonder was it due to Myrcludex or due to 72w peginf therapy.
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Avatar universal
Hi. Happy New Year! Lab rest result 10.1.2020.
How is my laboratory test result?
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2 Comments
Lab test result 10.1.2020. P-Krea 49, Pt-GFReEPi 118, P-CRP <1, P-Alb 38, P-ASAT 107, P-ALAT 143, P-AFOS 79,
B-TVK-KDIFFI, B-Trom 146, L-Monos 21.1, P-TT-INR. I am waiting other test result from doctor.
Avatar universal
Hi. Happy New Year! Lab rest result 10.1.2020.
What is mean this blood test result?

P-Krea 49, Pt-GFReEPi 118, P-CRP <1, P-Alb 38, P-ASAT 107, P-ALAT 143, P-AFOS 79,

B-TVK-KDIFFI, B-Trom 146, L-Monos 21.1, P-TT-INR. I am waiting other test result from doctor.
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