HBs quantitative result after 9 months of 1 mg entecavir

[Constantin90]

What do you think about this result:

- HbeAg positive

- 1 year combo treatment Viread and interferon, time frame 2011-2012
- from 2012 to 2016 spring just Viread alone
- HbsAg quantitative in 2014 march around 25.000 UI/ml
- from 2016 spring to 2017 spring no treatment at all, I have stopped the antiviral treatment ( very strong flare alt and ast over 1500 units.
- from 2017 spring till present Entecavir 1 mg
- on 14 the of November 2017 HbsAg quantitative result 11.368,64 UI/ml
- still HbeAg positive

What do you think about HbsAg quantitative trend results?

Thank you all!

Constantin

[Aduiski]

I don't think anything conclusive can be said about your HbsAg quantitative trend. These results go up and down. The fact that you stopped taking the medicine and had a strong flare might have caused your HbsAg to go a bit down (but thats not considered much).

Why were you switched from tenofovir to entecavir? Tenofovir wasn't working well or some other reason?

[Constantin90]

Switching to Entecavir was due to medical insurance reason.

[melcul]

How come after 6 years of nucs you are still hbeAg positive and have detectable HBVDNA? and whi switch on entecavir after so many years of viread ?
You are F2 now, i've seen in a previous post, what was your fibrosis when you started taking nucs 6 years ago ?

[Constantin90]

Before any treatment in 2011 it was 6.8 kpa classified as fibrosis level between f0 to F1.