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Hep B non-responder risk
I am a male Hep B vaccine nonresponder and am seeing someone who is an asymptomatic Hep B carrier. As a non-responder, am I at increased risk? What activities are safe, e.g. oral (receiving/giving), french kissing, intercourse, etc? For most things it seems to say "no data on ..."
My intention of giving you this info was to show you that a lot of info can be found. Please do not take all that I have written or linked to as the final authority on these matters.
I am an engineer... the software and hardware kind.
I am an engineer... the software and hardware kind.
Thanks a lot for the information. Unfortunately I'm told the company that made the pre-S1 vaccine in the study either doesn't exist or no longer makes it. In any case, you seem to be very well-informed! Are you a doctor or in the health profession?
There are all kinds of people in India -- a few of us read TSE ;-). Are you in the UK?
Coming back to your questions:
A non responder is not at an increased risk: http://www.springerlink.com/content/m001246051n47443/
Anyway, about taking the 3 shots again: so far I have not come across any info that proves that the standard 0-1-6 timing is more effective than the accelerated 0-1-2-12 timing. I think you can do the latter again.
Does this [ http://www.hepb.org/professionals/vaccine_non-responders.htm ] help? According to this, you would not be called a non-responder yet.
If you fail to respond even after your second course, perhaps you can show your doctors this: http://www.bmj.com/cgi/content/full/314/7077/329
Looks like there is a lot of info about all this online! Perhaps you can google around a bit.
Kissing is generally considered safe -- the documents I have come across did not specify if they meant deep or shallow. http://www.popline.org/docs/1115/107079.html seems to recommend synthetic condoms over natural condoms for preventing HepB infections.
Coming back to your questions:
A non responder is not at an increased risk: http://www.springerlink.com/content/m001246051n47443/
Anyway, about taking the 3 shots again: so far I have not come across any info that proves that the standard 0-1-6 timing is more effective than the accelerated 0-1-2-12 timing. I think you can do the latter again.
Does this [ http://www.hepb.org/professionals/vaccine_non-responders.htm ] help? According to this, you would not be called a non-responder yet.
If you fail to respond even after your second course, perhaps you can show your doctors this: http://www.bmj.com/cgi/content/full/314/7077/329
Looks like there is a lot of info about all this online! Perhaps you can google around a bit.
Kissing is generally considered safe -- the documents I have come across did not specify if they meant deep or shallow. http://www.popline.org/docs/1115/107079.html seems to recommend synthetic condoms over natural condoms for preventing HepB infections.
Indeed it is a ref to TSE. I didn't know he was read in India today (he is hardly read even here), although he refers to India in some of his poems and writings . I have some reservations about him because he was an antisemite.
It may be premature to worry because what they did was to give me three shots one month apart (an accelerated course). It is I believe a yeast recombinant vaccine. The test I refer to was just before they gave me the third shot (to see if there was any titer at all from the first two). So I am still waiting for the final testing 6 weeks after the third shot, and then they plan to give me a booster.
Is a non-responder at a greater risk for infection, ie is the non-response due to some immune deficiency - possibly Hep B specific - that would also make them more prone to getting infected? Also, is a non-responder more likely to end up being a chronic carrier? There seems to be no data on any of this.
In the meantime, opinion seems to vary on what exactly is safe - some say kissing (even deep) is fine, oral both ways is fine, while others are more cautious. And there seem to be no transmission data on condom use.
It may be premature to worry because what they did was to give me three shots one month apart (an accelerated course). It is I believe a yeast recombinant vaccine. The test I refer to was just before they gave me the third shot (to see if there was any titer at all from the first two). So I am still waiting for the final testing 6 weeks after the third shot, and then they plan to give me a booster.
Is a non-responder at a greater risk for infection, ie is the non-response due to some immune deficiency - possibly Hep B specific - that would also make them more prone to getting infected? Also, is a non-responder more likely to end up being a chronic carrier? There seems to be no data on any of this.
In the meantime, opinion seems to vary on what exactly is safe - some say kissing (even deep) is fine, oral both ways is fine, while others are more cautious. And there seem to be no transmission data on condom use.
Is your nick not an allusion to J. Alfred Prufrock? (From the poem by T.S. Eliot)
6 week wait for testing? I am not clear about what you have done so far. Can you tell me exactly which vaccine you have used, and the timing of the doses?
6 week wait for testing? I am not clear about what you have done so far. Can you tell me exactly which vaccine you have used, and the timing of the doses?
What is Hepatitis B Core antibodies as i gave blood and they say i have a reactive to Hepatitis B what so i need to do and what further test must i take to be able to give blood again.
What do you mean, "nice nick, Al?"
Thanks for the info. I've had an accelerated course but not waited the full 6 weeks after the last shot. Do I need to try the series again but do the slow 6 month one this time? They only offer one option here, unless I pay. Is there some other kind I should try that is more immunoreactive?
Thanks for the info. I've had an accelerated course but not waited the full 6 weeks after the last shot. Do I need to try the series again but do the slow 6 month one this time? They only offer one option here, unless I pay. Is there some other kind I should try that is more immunoreactive?
Nice nick, Al !
Intercourse is safe if you practice safe sex guidelines -- condom, etc. Even saliva carries the virus but *typically* in concentration levels too low to infect.
Do tell more about your vaccination history. Most people, when they do not respond, try the series of 3 vaccines again -- and it usually works. Did you do that too? Did you try other HepB vaccines? There are a few options.
Intercourse is safe if you practice safe sex guidelines -- condom, etc. Even saliva carries the virus but *typically* in concentration levels too low to infect.
Do tell more about your vaccination history. Most people, when they do not respond, try the series of 3 vaccines again -- and it usually works. Did you do that too? Did you try other HepB vaccines? There are a few options.
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