Isoprinosine in the treatment of chronic active hepatitis type B

[stef2011]

i suggest to read the full study, this is very interesting because Isoprinosine is relatively free of side effects and sold as a supplement in few countries

https://www.researchgate.net/publication/274510041_Inosine_Pranobex_Isoprinosine_-_a_Potential_Adjuvant_in_the_Management_of_Chronic_HBV_Infection

After achieving a durable on-treatment virological response with NUC (nucleos(t)ide analogues), adding an immunomodulating agent seems to have beneficial effect on the course of chronic HBV disease. Methods: Nine patients were investigated (5 – HBeAg(-) and 4 – HBeAg(+). All patients achieved durable on-treatment virological response with NA and then Isoprinosine was added for a period of 21 to 27 months. Serum HBsAg and HBV DNA levels were evaluated at a 3-month interval. Aim: The aim of the present study was to evaluate the effect of adjuvant immunomodulation with Isoprinosine in patients with chronic HBV infection who achieved durable suppression of HBV DNA on-treatment with NUC. Results: In HBeAg-negative patients an initial increase of qHBsAg was observed in 4/5 of patients after the adding of Isoprinosine. On month 15 of combined therapy a reduction of more than 50% from the baseline HBsAg level was found in 4/5 of patients (P=0.043). In HBeAg-positive patients there was no significant reduction of HBsAg during the follow-up. A reduction of HBsAg levels (about 30%) from the baseline was established in 3/4 patients at month 18. In the remaining one patient a reduction of 70% was established at month 27. There was an initial increase of HBsAg in 3/4 patients. In 3/4 of the patients there was a negativation of HBeAg. Conclusion: After adding Isoprinosine to NA, HBeAg-loss was achieved in 3/4 of HBeAg positive patients. HBsAg decline was more pronounced in HBeAg-negative subjects, which was not observed in NUC monotherapy. Isoprinosine in combination with NUC is safe and well tolerated.

[Jatashankar]

This drug is not available readily in market. There are a few vendors available online. Someone else if started this medicine plz share ur progress here.

[Jatashankar]

Studyforhope steff2011 and other pro answerers do not respond now. Sad

[stef2011]

it is not an old post i just made it.while it is an old drug tried in 2015 on few hbv patients it makes sense to try it since cheap and available everywhere.

[adhbv]

I just made a quick follow up with the authors of the article but there are no more outcome or study of the effect of  Isoprinosine in patients with chronic HBV infection. Since it is cheap and available everywhere so the authors would have definitely tried on more patients. Before trying it ourself, just ask why more than three years has past, there are no more report on this?

[adhbv]

"Further studies are needed to define more accurately the efficacy and safety profile of this combination", more than three years have past, we need to find these "Further studies".

[stef2011]

i dont think there s any studies, the drug is not profitable at all for drug makers in general, i even found some makers took it off the market in italy but maybe one brand is still available i should check at pharmacy.poland has some brands online that sell worldwide but no shipments to italy, maybe it is off the market here

[Jatashankar]

Why raising such an old posts. These things showed no outcome like nitazoxanide, chloroquine, phyllanthus etc

[sorte]

I wonder if inosine, which is different form of isoprinosine and is sold as the supplement not medicine, may have similar beneficial effect. Studyforhope ?

[imran4535]

Thank you for sharing Stef2011. Good to hear from you as well, I have not been active on the site for many years. I guess the biggest challenge right now is the HBSAG that is integrated into the host genome it looks like no drugs can actually deal with that and that is the main reason there is no SVR for HBV right now.

[stef2011]

please let's keep this post update on this if any of us will try Isoprinosine.i'll be trying it by few months but not 100% sure because i just recovered my thyroid from pegintf damage and i want to be sure it gets back to full function before adding Isoprinosine, TSH 5 now ft4-ft3 norm, it would be best to wait to reach TSH 3.5
i guess Isoprinosine might help thyroid too but since i am autoantibodies negative it is not sure the type of damage peg did and i prefer wait till TSH fully normal

[stef2011]

old posters know the cure is replicor but there is too much commercial interest so i dont think we will have it available anytime soon.more than a decade is gone and even if it is the only HDV cure......  no signs to make it available

[Dees71]

Stef I am very much happy to hear from you, We are visiting this site only to see valuable posts of few  like you. please post once in a vial your valuable thoughts. That will give hope to us.

[imran4535]

Thank you stef2011, we'll keep an eye on this thread. Its very sad its been over a decade and not much progress on Replicor. Have you switched to TAF by the way?

[stef2011]

no i didn t trust the first studies made by gilead and indipendent studies found they only pushed some aspects of TAF.this said in case of side effects on bones and kidneys TAF is the best choice.my kidneys still look ok, i ll check bones soon but in my case with a slow decling hbsag i prefer to not change anything unless i have   damage from tdf

[imran4535]

stef2011 in your previous posts you had mentioned that Genotype C is the the most dangerous for HCC, but after doing a lot of research on Pubmed.gov I learned that Genotype D is just as bad. It is just that most of the studies have been done on Genotype C. With Genotype C there is less liver damage and HBV integration because most remain in the Immune Tolerant phase for decades, but with Genotype D there is a lot of immune activity. What are your thoughts?

[stef2011]

i ll be trying it myself in the near future, my hbsag is already on slow decline but anything that fasten hbsag without sides is welcome.the best try is peg+tdf again because hbsag 850iu/ml has very high chances to go very low or clear but side effects of peg were so severe, especially thyroid damage, that in my case i risk irreversible damage and new chronic diseases on thyroid so something like Isoprinosine is much better even if it doesn t work

[joc2011]

Thanks so much Stef2011. Excited to see you here. I will be researching this Isoprinosine. do u know anyone who is already taking this. Keen to know about any sides experienced so far

[stef2011]

no i dont know anybody who tried it, uric acid increase is mentioned as side effect, not in this study but in general, so it is best to check cystatin C, uric acid and creatinine while using it.uric acid is not a good marker of kidneys damage so a small increase of it might even be meanless.i don t see it reported on this hbv study but better check those tests while on it.anyway the best test that shows kidneys damage is cystatin C (abnormal thyroid function might interfere with this test).it acts very slow on hbsag but one patient had a fast response again we have nothing to lose on relatively safe/cheap substances like this