Newest Repac Abstract

[Aduiski]

HBsAg and HDV RNA reduction with REP 2139-Ca and peg-INF alpha 2a in chronic HBV/HDV infection.

Nucleic acid polymers (NAPs) inhibit the release of HBsAg and the NAP REP 2139 can efficiently clear HBsAg from the blood of patients with HBV mono-infection. REP 2139-Ca therapy combined with pegylated interferon alpha-2a is being evaluated in Caucasian patients with HBV/HDV co-infection (NCT02233075).
Patients received REP 2139-Ca once weekly for 15 weeks (500 mg) by 2 h IV infusion, followed by combined therapy for 15 weeks with pegylated interferon alpha-2a (180ug SC qW) with 250 mg REP 2139-Ca. Patients then transition to 33 weeks of pegylated interferon alpha-2a monotherapy. HDV RNA, HBV DNA, HBsAg and anti-HBs are followed every two weeks using standard assays (Robogene RT- PCR, Abbott RealTime HBV, Abbott Architect).
On treatment, observed HBsAg reductions are currently *5 logs in 6 patients (all \1 IU / ml), *3 logs in three patients and *0.5 to 1.5 logs in three patients. HDV RNA is currently undetectable in ten patients (*5 to 8 log reduction from baseline) with *3 and *5 log reductions observed in the other two patients. Substantial elevation (389–15,408 mIU/ml) of serum anti-HBs and the development of liver flares were only observed with the onset of exposure to pegy- lated interferon alpha-2a and was only evident in patients with serum HBsAg \1 IU / ml at the start of immunotherapy.
REP 2139-Ca is able to achieve rapid reductions in serum HBsAg and HDV RNA in Caucasian patients with HBV/HDV infection. REP 2139-Ca may become an important new therapeutic option for patients with chronic HBV/HDV infection.

[antistr]

change.org can be used for a petition.

[stef2011]

i open another post on zadaxin, see answer there

[stef2011]

the problem with this drug/company is that we have no info on hbsag quant, they only reported hbvdna.

it would be great to see its effect on low hbsag or combo with cuban vaccine

[OrientS]

Questions ..
first of all hi to everybody and to stef ..

iam here member since 2011 .. when i discovered that iam hbver chronic carrier iwas scared .. i was reading in this forum daily for about two years .. until a i started entecaver 0.5 mg .. now iam (Al7mdulillah) is F0 by fibrosan and und hbvdna .. with almot normal ast ..

i become visiting this forum every 2-3 months ..
it is the best place to get information and exellent advises ..

sorry for the no need introduction ..

is zadaxin is alhpha thmosin?

what is the recommended dose with entecavir?

is there any side effects?

last HBsAg quantitive for me is around 600 iu/ml by roche

less than 1000 iu/ml

from where can i get zadaxin?

thanks for all

[Aduiski]

studyforhope...

Could you please provide your opinion on the most effective long-term approach to  treatment, taking into account the available options such as entecavir/tenofovir, pegasys, zadaxin (thymosin alpha), etc....

Basically, my question is, what would be the advised or seemingly most-effective sequence of the treatment options and when (e.g. at what hbsag level) would each of these medicines be best to be initiated.

Lets say one starts with tenofovir/entecavir...at what time would be the most effective to add pegasys and/or thymosin alpha?

Thanks in advance...

[studyforhope]

This is a thread about rep9ac, so this much more general question would get lost and diluted in this context.

[sorte]

Thanks. Any theories why in that case with naps it's better than interferon and in other cases not ?

[studyforhope]

Thymosin  alpha fosters t cell responses. Direct comparisons with interferon were rarely made.
it might also be that the antibody level is raised more effectively, protecting the svr status better.

[stef2011]

it worked this way on nap but who knows monotherapy