One key question would be that these FLARES that kill off the virus, are they so strong that they will cause HCC integration?
Y will you disturb the natural program of the cells. Their deaths are predecided by the body if u induce death in them that may trigger status me very noxious chain reactions
finally somebody did a study on it, we always knew it is an hbv cure and the fact such a low single dose lowered hbsag without sides definitely makes it off label hbv cure.let's see in which country this might be possible...
This seems to be very promising, activating the inactivated T-cells, especially the ones in hepatocytes would be very promising to rid the hbv infected liver cells. Combine this with nucs to remove the virus from the blood, then it would cure the disease. But, I wonder whether all the infected hypatocytes would be targetted, especially those cells that have integrated hbv-dna in their genome? Plus, these researche take years if not decades to materialise into real drugs, so quite disappointing the pace at which the drugs are developed. I think the big drug companies that conrol the medication against hepB, like Gilead, are too much power. What would these companies and their investors do, if suddenly, someone develops a drug that cures hbv with few doses in a matter of few weeks? Their billions of income would suddenly disappear, so these guys want to keep us on nucs, so that we never get cured but continue to buy their drugs for our entire lives, very sad!
It is very expensive around 2000$ per 100mg vial. Who can bear this and also the health hazards on healthy body
Treatment with nivolumab is generally safe. More than 10% of treated participants had seriously elevated liver enzymes and 5% developed immune-mediated hepatitis requiring corticosteroids. The major concern with checkpoint inhibitors like nivolumab is immune-related adverse events; the drugs work by restoring immune responses against cancer cells, but they can also cause excessive inflammation of healthy tissue.