Results after 44 weeks of TDF+Peg+NTZ

[April9903]

In March 2012 (Before Treatment)
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HBV DNA --  450,897 copies/ml
HBsAg (Quantitative) --  3054.03 IU/ml (cut off= 0.05 IU/ml)
HbeAg  -- Neg
AntiHbe -- Pos
Fibroscan =  4.2 Kpa
Geno Type C
Precore BCP ( T 1762 / A 1764 ) Mu
PC codon 28 Mu


22-October 2012 (After 12 weeks of PEG + TDF + NTZ )
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HBV DNA --  186 copies/ml
HBsAg (Quantitative) --  2869.70 IU/ml (cut off= 0.05 IU/ml)
25-OH vit D3 --61.3 ug/l
ALT - 81 u/l
AST - 89 u/l
Platelet Count is low - 140


31-December 2012 (After 24 weeks of PEG + TDF + NTZ )
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HBV DNA --  UND
HBsAg (Quantitative) --  2606.72 IU/ml (cut off= 0.05 IU/ml)
25-OH vit D3 --   46.1 ug/l
ALT - 52 u/l
AST - 63 u/l
Platelet Count is normal - 150
Fibroscan =  6.1 Kpa

15-May 2013 (After 44 weeks of PEG + TDF + NTZ )
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HBV DNA --  UND
HBsAg (Quantitative) --  2612.48 IU/ml (cut off= 0.05 IU/ml)
25-OH vit D3 --   54.8 ng/ml
ALT - 84 u/l
AST - 80 u/l
Platelet Count is normal - 177

Last week, I had the last shot of Peg. I am very disappointed with my HbsAg results. It's not going down anymore. Doc said the effect of Peg will stay on very long even after the last shot. I continue taking TDF but stopped NTZ now. My Alt and Ast is also still high. Very disappointed!

[stef2011]

no it is best to stop and restart it later on, she won t lose the effect of this 48weeks treatment if she restarts in 1-2years

[andrey19]

There are studies saying that prolonged 96 weeks is safe and has response rate of almost 30% against 7% comparing to 48 week of interferon. I think if you can bear sides and high cost of pegasys just give yourself a chance and continue interferon.

[stef2011]

i havent seen enough studies on this i prefer maitake only for now which is the most studied in vivo

[April9903]

@calebz..I'll again check with fibroscan in September.

@stef2011..Thanks for the link. I saw in other thread that you are taking Mitake muchroom supplement. Do you know about Lingzhi muchroom?

[stef2011]

http://www.mvlabyzh.fudan.edu.cn/admin/pic/uploadfile/2013052357155265.pdf

extremely interesting, especially the part of hbvdna intf alpha suppression, this is probably one of the reasons sequantial therapy works and pegintf mono doesnt

[stef2011]

Throughout the tx I lost a lot of hair and had flu like symptoms and tiredness, wired headaches, sometimes more, sometimes less

dont worry the hair will come back 3-4 months after you stop, i also had all that by imiquimod and i think pegintf was a good try anyway you will benefit a little while on tdf mono anyway
the paracetamol taken while on peg is no problem if doses are low and correct for liver disease

your fibroscan is not much different, 6kpa is still healthy rage and that is probably just a little inflammation by the immune response made by peg, this will go down in few months too