HBsAg is Hepatitis B "s"urface Anti"g"en. It is the virus.
The e-antigen (envelope antigen) is a protein that attaches itself to the virus in its more virulent phase.
I have not heard about more HCC in normally functioning livers. The vast majority of HCCs occur in livers that are cirrhotic. Often cirrhotic livers do show normal ALT as there are not enough liver cells left to die off.
Guys,
What does HBsAg & hbeag stand for? I know one means E-antigen and the other obviously means e-antibody.. As bberry explained most hepotama's occur in normal liver functions would there not be a higher ratio to those who are actually e-antigen positive as it is an indication that liver damages is occurring to a higher degree...?
pete
most seroconvert either way..sometime in life . some do it eaiser and faster than others.
at least this is what med journals online claim.
yes spontaneous seroconversion is better...
still though, seroconversion with meds requiores close monitoring after come offs meds for some time .. maybe a year or so until doctors think patient is safe and consistance enough with safe blood results to go on in life without meds..
hope that makes sense
Thanks guys.
I also wondered what the chances of sero-conversion in patients who take medication is compared to those who don't. Obviously those who achieve this status without any help at all would probably fare better in later life (as in no sudden VL increase or the virus attacking the liver with major force).
hi what is the best medicine for me to take so that my hbeag would become non reactive....my last count is 387.700 i know dat is to much....i want to become non infectious...tnx
moreover, a seroconversion from e positive to e negative is best desired when it happens spontaneously rathethan through medication.
as for what brit said about "converting" from hbsag postive to negative , this is what is called "resolved hbv" rather than seroconversion. like zlly said it is mostly used for the e antigen going from postive to negative.
still no gurantees that a "settled" mode that the liver experiences after having seroconverted by any chance means " safe" mode. it can still do harm if it wants to.. just not as bad as if you were highly infectious with hbeag postive . most hepatomas occur with people in normal liver funtions and hbeag negative.. so close monitoring is still needed every 3-6 months depending on your doctor's call.
britgirl is mostly right.
1. This is e-seroconversion...from positive to negative with e-antibodies. It is the preferred state for chronic HBers. However, there is no guarantee that liver damage is not occurring at some level at this stage. It is probably minimal but we really don't know. That's why we continue to monitor for life.
Hey Peteshine,
My understanding of seroconversion is that you have:
1. seroconversion when your HBe antigen turns negative and then the antibody to it appears positive. This is good for any chronic carrier. It means your liver is not being damaged by the virus but it can change back at any time and this is why you must be monitored every few months by your doctor.
2. Then there is the sero-conversion from HBsAg positive to HBsAg negative but that is usually only achieved by acute HBVers. Altho it can take place in 2-5% of chronics per year.
Hope this helps. What has your doc told you about your sero=conversion?
Brit