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Tenofovir side effects

Hi has anyone suffered any side effects from taking tenofovir for hep b.
My husband has been taking them now for 4 years... he still get very fatigued in an afternoon.. however, much less now then before he started on the meds.
He is suffeing from pain in his bicep, the dog pulled on the leash when he took her for a walk and he pulled a muscle   since then its gotten worse and worse, it doesnt seem to be healing ... its seems like he is suffering weakness in his muscles.... his hair is thinning in patches all over also (could be down to his age,) , he has now shaved it all off ... he also gets itchy skin and hive like bumps on his hands.  Could all of this be related ... he sometimes complains of kidney pain ..
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